Next Article in Journal
Herpes Simplex Virus Establishment, Maintenance, and Reactivation: In Vitro Modeling of Latency
Previous Article in Journal
Influenza-Omics and the Host Response: Recent Advances and Future Prospects
Previous Article in Special Issue
Toxoplasma gondii in the Food Supply
Article Menu

Export Article

Open AccessArticle
Pathogens 2017, 6(2), 26; doi:10.3390/pathogens6020026

IgG Avidity Test in Congenital Toxoplasmosis Diagnoses in Newborns

1
Department of Gynecology and Obstetrics, Faculty of Medicine, Federal University of Goias (UFG), Goiania GO 74045-155, Brazil
2
Laboratory of Immunology of Clinical Hospital of UFG, Goiania GO 74605-020, Brazil
3
Department of Gynecology, Faculty of Medicine, Federal University of São Paulo, São Paulo SP 04039-032, Brazil
4
Department of Microbiology, Immunology, Parasitology and Pathology, Institute of Tropical Pathology and Public Health, UFG, Goiania GO 74605-450, Brazil
*
Author to whom correspondence should be addressed.
Received: 7 March 2017 / Revised: 9 June 2017 / Accepted: 11 June 2017 / Published: 18 June 2017
(This article belongs to the Special Issue Toxoplasma gondii Infection)
View Full-Text   |   Download PDF [469 KB, uploaded 21 June 2017]   |  

Abstract

The goal of this study was to investigate the importance of IgG avidity testing in newborns (NBs) diagnosed with early congenital toxoplasmosis. We collected samples from 88 puerperae infected by Toxoplasma gondii (T. gondii) and their NBs (48 acutely-infected puerperae (AIP) and 40 chronically-infected puerperae (CIP)), from two public maternity hospitals in Goiania city, Goias, Brazil, from 2010 to 2015. Specific anti-T. gondii IgM and IgG serum levels and IgG avidity tests were evaluated using chemiluminescence. Congenital toxoplasmosis was observed in 66.66% (n = 32) of NBs with AIP, 94.1% presenting low avidity (LA) and 51.61% presenting high avidity (HA) test results. The IgG and IgM levels of NBs with LA and their puerperae were higher in comparison with HA NBs and puerperae (p = 0.0001). The avidity tests showed 100% specificity and 50% sensitivity (p = 0.0001). NBs with LA had a 15-fold increased risk of developing congenital toxoplasmosis in comparison with HA NBs. The IgG avidity test could be used to assist in early congenital toxoplasmosis diagnoses in NBs and LA, identifying a greater probability of vertical transmission. View Full-Text
Keywords: congenital toxoplasmosis; IgG avidity; diagnoses; newborns; puerperae congenital toxoplasmosis; IgG avidity; diagnoses; newborns; puerperae
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Fonseca, Z.C.; Rodrigues, I.M.X.; Melo, N.C.; Avelar, J.B.; Castro, A.M.; Avelino, M.M. IgG Avidity Test in Congenital Toxoplasmosis Diagnoses in Newborns. Pathogens 2017, 6, 26.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Pathogens EISSN 2076-0817 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top