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Pathogens 2017, 6(2), 25; doi:10.3390/pathogens6020025

Influenza-Omics and the Host Response: Recent Advances and Future Prospects

1
Biomarkers Division, Battelle Memoria Institute, Aberdeen, MD 21001, USA
2
Earth and Biological Sciences Directorate, Pacific Northwest National Laboratory, Richland, WA 99352, USA
*
Author to whom correspondence should be addressed.
Received: 26 April 2017 / Revised: 7 June 2017 / Accepted: 8 June 2017 / Published: 10 June 2017
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Abstract

Influenza A viruses (IAV) continually evolve and have the capacity to cause global pandemics. Because IAV represents an ongoing threat, identifying novel therapies and host innate immune factors that contribute to IAV pathogenesis is of considerable interest. This review summarizes the relevant literature as it relates to global host responses to influenza infection at both the proteome and transcriptome level. The various-omics infection systems that include but are not limited to ferrets, mice, pigs, and even the controlled infection of humans are reviewed. Discussion focuses on recent advances, remaining challenges, and knowledge gaps as it relates to influenza-omics infection outcomes. View Full-Text
Keywords: influenza; transcriptomics; proteomics influenza; transcriptomics; proteomics
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Powell, J.D.; Waters, K.M. Influenza-Omics and the Host Response: Recent Advances and Future Prospects. Pathogens 2017, 6, 25.

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