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Pathogens 2016, 5(4), 62; doi:10.3390/pathogens5040062

Distribution of Type I Restriction–Modification Systems in Streptococcus suis: An Outlook

1
Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
2
Department of Global Health-Amsterdam Institute for Global Health and Development, Academic Medical Center, University of Amsterdam, Pietersbergweg 17, 1105 BM Amsterdam, The Netherlands
*
Author to whom correspondence should be addressed.
Academic Editor: Mariela Segura
Received: 18 July 2016 / Revised: 7 November 2016 / Accepted: 12 November 2016 / Published: 18 November 2016
(This article belongs to the Special Issue Streptococcus suis)
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Abstract

Streptococcus suis is a porcine commensal and pathogen with zoonotic potential. We recently identified a novel Type I restriction–modification (R–M) system in a zoonotic S. suis clone which has emerged in the Netherlands. Here, we describe the DNA inversions in the specificity subunit of this system in S. suis serotype 2, clonal complex 20 and explain the absence of domain movement by the absence of repeats. In addition, we identified a core Type I R–M system present in 95% of the isolates and found an association of the distribution of Type I R–M systems in the S. suis genome with population structure. We speculate on the potential role of Type I R–M systems in S. suis given the recently described associations of Type I R–M systems with virulence and propose future research directions. View Full-Text
Keywords: Streptococcus suis; prophage; Type I restriction–modification system; pfam; genomic analysis; DNA inversions Streptococcus suis; prophage; Type I restriction–modification system; pfam; genomic analysis; DNA inversions
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Willemse, N.; Schultsz, C. Distribution of Type I Restriction–Modification Systems in Streptococcus suis: An Outlook. Pathogens 2016, 5, 62.

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