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Pathogens 2016, 5(4), 59; doi:10.3390/pathogens5040059

Advocating for both Environmental and Clinical Approaches to Control Human Strongyloidiasis

School of the Environment, Flinders University, GPO Box 2100, Adelaide 5001, Australia
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Academic Editor: Lawrence Young
Received: 9 June 2016 / Revised: 25 September 2016 / Accepted: 28 September 2016 / Published: 30 September 2016
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Abstract

Strongyloidiasis is an underestimated disease caused by the soil-transmitted parasite of the genus Strongyloides. It is prevalent in socioeconomically disadvantaged communities and it is estimated that global infection could be as high as 370 million people. This paper explores current methods of strongyloidiasis treatment, which rely on administration of anthelminthic drugs. However these drugs cannot prevent reinfection and drug resistance has already been observed in veterinary models. This highlights the need for a combined approach for controlling Strongyloides that includes both clinical treatment and environmental control methods. Currently, nematicides are widely used to control plant parasites. The review suggests that due to the species’ similarity and similar modes of action, these nematicides could also be used to control animal and human parasitic nematodes in the environment. View Full-Text
Keywords: strongyloidiasis; Strongyloides stercoralis; anthelminthic drugs; nematicides; ivermectin; resistance strongyloidiasis; Strongyloides stercoralis; anthelminthic drugs; nematicides; ivermectin; resistance
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Beknazarova, M.; Whiley, H.; Ross, K. Advocating for both Environmental and Clinical Approaches to Control Human Strongyloidiasis. Pathogens 2016, 5, 59.

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