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Pathogens 2015, 4(3), 639-661; doi:10.3390/pathogens4030639

Systems Level Dissection of Candida Recognition by Dectins: A Matter of Fungal Morphology and Site of Infection

1
Research and Innovation Center, Fondazione E. Mach, via E. Mach 1, San Michele all’Adige (TN) 38010, Italy
2
Department of Neuroscience, Psychology, Drug Research and Child Health (Neurofarba), University of Florence, Firenze 50139, Italy
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Sarah Gaffen
Received: 11 July 2015 / Revised: 17 August 2015 / Accepted: 17 August 2015 / Published: 21 August 2015
(This article belongs to the Special Issue Candida Albicans Infections)
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Abstract

Candida albicans is an ubiquitous fungal commensal of human skin and mucosal surfaces, and at the same time a major life-threatening human fungal pathogen in immunocompromised individuals. Host defense mechanisms rely on the capacity of professional phagocytes to recognize Candida cell wall antigens. During the past decade, the host immune response to Candida was dissected in depth, highlighting the essential role of C-type lectin receptors, especially regarding the power of the Dectins’ family in discriminating between the tolerated yeast-like form of Candida and its invading counterpart, the hyphae. This review focuses on the immuno-modulatory properties of the Candida morphologies and their specific interactions with the host innate immune system in different body surfaces. View Full-Text
Keywords: Candida albicans; innate immunity; morphology; C-type lectin receptors; pathogen; yeast-hyphae Candida albicans; innate immunity; morphology; C-type lectin receptors; pathogen; yeast-hyphae
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Rizzetto, L.; Weil, T.; Cavalieri, D. Systems Level Dissection of Candida Recognition by Dectins: A Matter of Fungal Morphology and Site of Infection. Pathogens 2015, 4, 639-661.

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