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Pathogens 2015, 4(3), 606-619; doi:10.3390/pathogens4030606

Interleukin 17-Mediated Host Defense against Candida albicans

Section of Immunology, Institute of Virology, University of Zürich, Winterthurerstrasse 266a, Zürich, CH-8057, Switzerland
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Academic Editor: Sarah Gaffen
Received: 17 July 2015 / Revised: 6 August 2015 / Accepted: 7 August 2015 / Published: 12 August 2015
(This article belongs to the Special Issue Candida Albicans Infections)
View Full-Text   |   Download PDF [210 KB, uploaded 12 August 2015]

Abstract

Candida albicans is part of the normal microbiota in most healthy individuals. However, it can cause opportunistic infections if host defenses are breached, with symptoms ranging from superficial lesions to severe systemic disease. The study of rare congenital defects in patients with chronic mucocutaneous candidiasis led to the identification of interleukin-17 (IL-17) as a key factor in host defense against mucosal fungal infection. Experimental infections in mice confirmed the critical role of IL-17 in mucocutaneous immunity against C. albicans. Research on mouse models has also contributed importantly to our current understanding of the regulation of IL-17 production by different cellular sources and its effector functions in distinct tissues. In this review, we highlight recent findings on IL-17-mediated immunity against C. albicans in mouse and man. View Full-Text
Keywords: interleukin 17; chronic mucocutaneous candidiasis; mouse models interleukin 17; chronic mucocutaneous candidiasis; mouse models
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Sparber, F.; LeibundGut-Landmann, S. Interleukin 17-Mediated Host Defense against Candida albicans. Pathogens 2015, 4, 606-619.

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