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Pathogens 2015, 4(3), 662-681; doi:10.3390/pathogens4030662

Nonhuman Primate Models of Chikungunya Virus Infection and Disease (CHIKV NHP Model)

1
Vaccine & Gene Therapy Institute, Oregon Health & Science University, 505 NW 185th Ave, Beaverton, OR 97006, USA
2
Division of Biomedical Sciences, School of Medicine, University of California-Riverside, Riverside, CA 92521, USA
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Thomas E. “Tem” Morrison
Received: 17 August 2015 / Revised: 4 September 2015 / Accepted: 9 September 2015 / Published: 16 September 2015
(This article belongs to the Special Issue Viral Pathogenesis)
View Full-Text   |   Download PDF [233 KB, uploaded 16 September 2015]

Abstract

Chikungunya virus (CHIKV) is a positive-sense RNA virus transmitted by Aedes mosquitoes. CHIKV is a reemerging Alphavirus that causes acute febrile illness and severe and debilitating polyarthralgia of the peripheral joints. Huge epidemics and the rapid spread of CHIKV seen in India and the Indian Ocean region established CHIKV as a global health concern. This concern was further solidified by the recent incursion of the virus into the Western hemisphere, a region without pre-existing immunity. Nonhuman primates (NHPs) serve as excellent animal models for understanding CHIKV pathogenesis and pre-clinical assessment of vaccines and therapeutics. NHPs present advantages over rodent models because they are a natural amplification host for CHIKV and they share significant genetic and physiological homology with humans. CHIKV infection in NHPs results in acute fever, rash, viremia and production of type I interferon. NHPs develop CHIKV-specific B and T-cells, generating neutralizing antibodies and CHIKV-specific CD4+ and CD8+ T-cells. CHIKV establishes a persistent infection in NHPs, particularly in cynomolgus macaques, because infectious virus could be recovered from spleen, liver, and muscle as late as 44 days post infection. NHPs are valuable models that are useful in preclinical testing of vaccines and therapeutics and uncovering the details of CHIKV pathogenesis. View Full-Text
Keywords: chikungunya virus; nonhuman primate; polyarthritis; pathogenesis; immunity chikungunya virus; nonhuman primate; polyarthritis; pathogenesis; immunity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Broeckel, R.; Haese, N.; Messaoudi, I.; Streblow, D.N. Nonhuman Primate Models of Chikungunya Virus Infection and Disease (CHIKV NHP Model). Pathogens 2015, 4, 662-681.

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