Pathogens 2014, 3(1), 1-13; doi:10.3390/pathogens3010001

Healthcare Workers’ Hand Microbiome May Mediate Carriage of Hospital Pathogens

1email, 1email, 2email, 1email and 1,* email
Received: 11 October 2013; in revised form: 26 November 2013 / Accepted: 19 December 2013 / Published: 27 December 2013
(This article belongs to the Special Issue Gut Microbiome)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: One function of skin microbiota is to resist colonization and infection by external microorganisms. We sought to detect whether the structure of the hand microbiota of 34 healthcare workers (HCW) in a surgical intensive care unit mediates or modifies the relationship between demographic and behavioral factors and potential pathogen carriage on hands after accounting for pathogen exposure. We used a taxonomic screen (16S rRNA) to characterize the bacterial community, and qPCR to detect presence of Staphylococcus aureus, Enterococcus spp., methicillin-resistant Staphylococcus aureus (MRSA), and Candida albicans on their dominant hands. Hands were sampled weekly over a 3-week period. Age, hand hygiene, and work shift were significantly associated with potential pathogen carriage and the associations were pathogen dependent. Additionally, the overall hand microbiota structure was associated with the carriage of potential pathogens. Hand microbiota community structure may act as a biomarker of pathogen carriage, and modifying that structure may potentially limit pathogen carriage among HCW.
Keywords: skin; hand; microbiome; microbiota; hand hygiene; healthcare; pathogen
PDF Full-text Download PDF Full-Text [687 KB, uploaded 27 December 2013 18:22 CET]

Export to BibTeX |

MDPI and ACS Style

Rosenthal, M.; Aiello, A.; Larson, E.; Chenoweth, C.; Foxman, B. Healthcare Workers’ Hand Microbiome May Mediate Carriage of Hospital Pathogens. Pathogens 2014, 3, 1-13.

AMA Style

Rosenthal M, Aiello A, Larson E, Chenoweth C, Foxman B. Healthcare Workers’ Hand Microbiome May Mediate Carriage of Hospital Pathogens. Pathogens. 2014; 3(1):1-13.

Chicago/Turabian Style

Rosenthal, Mariana; Aiello, Allison; Larson, Elaine; Chenoweth, Carol; Foxman, Betsy. 2014. "Healthcare Workers’ Hand Microbiome May Mediate Carriage of Hospital Pathogens." Pathogens 3, no. 1: 1-13.

Pathogens EISSN 2076-0817 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert