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Pathogens 2014, 3(1), 1-13; doi:10.3390/pathogens3010001
Article

Healthcare Workers’ Hand Microbiome May Mediate Carriage of Hospital Pathogens

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Received: 11 October 2013; in revised form: 26 November 2013 / Accepted: 19 December 2013 / Published: 27 December 2013
(This article belongs to the Special Issue Gut Microbiome)
View Full-Text   |   Download PDF [687 KB, uploaded 27 December 2013]
Abstract: One function of skin microbiota is to resist colonization and infection by external microorganisms. We sought to detect whether the structure of the hand microbiota of 34 healthcare workers (HCW) in a surgical intensive care unit mediates or modifies the relationship between demographic and behavioral factors and potential pathogen carriage on hands after accounting for pathogen exposure. We used a taxonomic screen (16S rRNA) to characterize the bacterial community, and qPCR to detect presence of Staphylococcus aureus, Enterococcus spp., methicillin-resistant Staphylococcus aureus (MRSA), and Candida albicans on their dominant hands. Hands were sampled weekly over a 3-week period. Age, hand hygiene, and work shift were significantly associated with potential pathogen carriage and the associations were pathogen dependent. Additionally, the overall hand microbiota structure was associated with the carriage of potential pathogens. Hand microbiota community structure may act as a biomarker of pathogen carriage, and modifying that structure may potentially limit pathogen carriage among HCW.
Keywords: skin; hand; microbiome; microbiota; hand hygiene; healthcare; pathogen skin; hand; microbiome; microbiota; hand hygiene; healthcare; pathogen
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Rosenthal, M.; Aiello, A.; Larson, E.; Chenoweth, C.; Foxman, B. Healthcare Workers’ Hand Microbiome May Mediate Carriage of Hospital Pathogens. Pathogens 2014, 3, 1-13.

AMA Style

Rosenthal M, Aiello A, Larson E, Chenoweth C, Foxman B. Healthcare Workers’ Hand Microbiome May Mediate Carriage of Hospital Pathogens. Pathogens. 2014; 3(1):1-13.

Chicago/Turabian Style

Rosenthal, Mariana; Aiello, Allison; Larson, Elaine; Chenoweth, Carol; Foxman, Betsy. 2014. "Healthcare Workers’ Hand Microbiome May Mediate Carriage of Hospital Pathogens." Pathogens 3, no. 1: 1-13.

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