Special Issue "Gut Microbiome"

Guest Editor
Prof. Dr. Jean E. Crabtree
Molecular Gastroenterology Section, Leeds Institute of Molecular Medicine, Wellcome Trust Brenner Building, St. James's University Hospital, Leeds LS9 7TF, UK
Website: http://www.limm.leeds.ac.uk/research_sections/molecular_gastroenterology/groups/crabtree.htm
E-Mail: j.crabtree@leeds.ac.uk
Interests: Helicobacter pylori; host-pathogen interactions in gastrointestinal tract; infection and gastrointestinal cancer; mucosal immunology

Co-Guest Editor
Prof. Dr. Lars Engstrand
Department of Microbiology, Tumor and Cell Biology for Life Laboratory, Karolinska Institute, Stockholm, Sweden
Website: http://ki.se/ki/jsp/polopoly.jsp?d=3210&l=en
E-Mail: lars.engstrand@ki.se
Phone: +46 70 678 0318
Interests: role of Gut microbiota in health and disease; Helicobacter pylori associated diseases; Population-based epidemiological studies of the gut system

Dear Colleagues,

Advances in metagenomics and bioinformatics are pioneering our understanding of the gut microbiota in health and disease. Phylum level differences in gut microbiota occur in many clinical conditions bringing the opportunity that manipulation of the gut microbiome may be a way to impact on multiple diseases. The gut microbiome can modify human physiology influencing nutrient extraction from dietary intake and effect gut mucosal immune responses contributing to both the maturation of the gut immune system as well as autoimmune diseases. The Human Microbiome Project has identified the normal gut microbiome in individuals in developed countries. There is little data on the normal human gut microbiome in developing countries and the impact of global dietary variations.  Exciting recent data indicate that the gut microbiome can contribute to both malnutrition and obesity and that exposure to antibiotics early in life can lead to increased adiposity. Also, antibiotic overuse will kill beneficial bacteria. Diet impacts on the composition of the gut microbiome opening the opportunity for therapeutic dietary manipulation of gut microbiota. We look forward to your contributions and to a valuable edition that will promote further developments in this exciting field.

Prof. Dr. Jean E. Crabtree
Prof. Dr. Lars Engstrand
Guest Editors

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