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Pathogens 2013, 2(3), 472-505; doi:10.3390/pathogens2030472
Review

Kuru: A Journey Back in Time from Papua New Guinea to the Neanderthals’ Extinction

Received: 19 June 2013; in revised form: 4 July 2013 / Accepted: 12 July 2013 / Published: 18 July 2013
(This article belongs to the Special Issue Prions)
Abstract: Kuru, the first human transmissible spongiform encephalopathy was transmitted to chimpanzees by D. Carleton Gajdusek (1923–2008). In this review, I briefly summarize the history of this seminal discovery along its epidemiology, clinical picture, neuropathology and molecular genetics. The discovery of kuru opened new windows into the realms of human medicine and was instrumental in the later transmission of Creutzfeldt-Jakob disease and Gerstmann-Sträussler-Scheinker disease as well as the relevance that bovine spongiform encephalopathy had for transmission to humans. The transmission of kuru was one of the greatest contributions to biomedical sciences of the 20th century.
Keywords: kuru; prion diseases; neuropathology; D. Carleton Gajdusek kuru; prion diseases; neuropathology; D. Carleton Gajdusek
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Liberski, P.P. Kuru: A Journey Back in Time from Papua New Guinea to the Neanderthals’ Extinction. Pathogens 2013, 2, 472-505.

AMA Style

Liberski PP. Kuru: A Journey Back in Time from Papua New Guinea to the Neanderthals’ Extinction. Pathogens. 2013; 2(3):472-505.

Chicago/Turabian Style

Liberski, Pawel P. 2013. "Kuru: A Journey Back in Time from Papua New Guinea to the Neanderthals’ Extinction." Pathogens 2, no. 3: 472-505.


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