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Pathogens, Volume 10, Issue 1

2021 January - 85 articles

Cover Story: We describe a COVID-19 outbreak with a high infection and mortality rate among 116 nursing home residents in Rhode Island, USA. While typical symptoms of fever and cough were prevalent, shortness of breath was rarely found despite common hypoxemia. The majority of patients demonstrated atypical symptoms, most common being loss of appetite, lethargy, diarrhea, and fatigue. Mortality was associated with rapid clinical decline beginning with loss of appetite and lethargy and more often involving fever >38 °C, loss of appetite, altered mental status, diarrhea, and respiratory distress. No differences in age or comorbidities were associated with mortality. Treatment with anticoagulation was associated with reduced mortality. Overall, the clinical features of COVID-19 in this population can be subtle and the symptoms commonly atypical. View this paper
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Articles (85)

  • Article
  • Open Access
21 Citations
8,127 Views
16 Pages

Accurate Diagnosis of Small Ruminant Lentivirus Infection Is Needed for Selection of Resistant Sheep through TMEM154 E35K Genotyping

  • Hugo Ramírez,
  • Irache Echeverría,
  • Alfredo A. Benito,
  • Idoia Glaria,
  • Julio Benavides,
  • Valentín Pérez,
  • Damián de Andrés and
  • Ramsés Reina

19 January 2021

Small ruminant lentiviruses (SRLV) cause an incurable multiorganic disease widely spread in sheep and goats that disturbs animal welfare and production. In the absence of a vaccine, control measures have been traditionally based on early diagnosis an...

(This article belongs to the Section Viral Pathogens)
  • Review
  • Open Access
88 Citations
12,209 Views
15 Pages

19 January 2021

African swine fever (ASF) is a notifiable viral disease of pigs and wild boars that could lead to serious economic losses for the entire European pork industry. As no effective treatment or vaccination is available, disease prevention and control rel...

(This article belongs to the Special Issue African Swine Fever Virus Infection)
  • Article
  • Open Access
29 Citations
7,070 Views
21 Pages

Further In Vitro Assessment and Mid-Term Evaluation of Control Strategy of Xylella fastidiosa subsp. pauca in Olive Groves of Salento (Apulia, Italy)

  • Giuseppe Tatulli,
  • Vanessa Modesti,
  • Nicoletta Pucci,
  • Valeria Scala,
  • Alessia L’Aurora,
  • Simone Lucchesi,
  • Manuel Salustri,
  • Marco Scortichini and
  • Stefania Loreti

19 January 2021

During recent years; Xylella fastidiosa subsp. pauca (Xfp) has spread in Salento causing relevant damage to the olive groves. Measures to contain the spreading of the pathogen include the monitoring of the areas bordering the so-called “infecte...

(This article belongs to the Special Issue Progress on Understanding and Management of Xylella fastidiosa Infections)
  • Article
  • Open Access
23 Citations
4,236 Views
10 Pages

Predominance of Candida Glabrata among Non-albicans Candida Species in a 16-Year Study of Candidemia at a Tertiary Care Center in Lebanon

  • Aline El Zakhem,
  • Rachid Istambouli,
  • Maria Alkozah,
  • Amal Gharamti,
  • Mohamad Ali Tfaily,
  • Jean-Francois Jabbour,
  • George F. Araj,
  • Hani Tamim and
  • Souha S. Kanj

19 January 2021

Background: Candidemia is associated with a high mortality rate, and its incidence is increasing worldwide with a rise in non-albicans candidemia (NAC). Epidemiologic data from Arab countries are scarce and there are no data from Lebanon; Methods: Th...

(This article belongs to the Special Issue Uncommon Candida and Other Opportunistic Yeast-Like Fungi: Diagnosis and Treatment)
  • Article
  • Open Access
14 Citations
3,988 Views
14 Pages

The Role of a New Compound Micronutrient Multifunctional Fertilizer against Verticillium dahliae on Cotton

  • Yalin Zhang,
  • Lihong Zhao,
  • Zili Feng,
  • Hongfu Guo,
  • Hongjie Feng,
  • Yuan Yuan,
  • Feng Wei and
  • Heqin Zhu

19 January 2021

Verticillium dahliae Kleb., the causal pathogen of vascular wilt, can seriously reduce the yield and quality of many crops, including cotton (Gossypium hirsutum). To control the harm caused by V. dahliae, considering the environmental pollution of ch...

  • Article
  • Open Access
13 Citations
4,751 Views
8 Pages

Changes in the Splenic Melanomacrophage Centre Surface Area in Southern Bluefin Tuna (Thunnus maccoyii) Are Associated with Blood Fluke Infections

  • Barbara F. Nowak,
  • Mai Dang,
  • Claire Webber,
  • Lukas Neumann,
  • Andrew Bridle,
  • Roberto Bermudez and
  • Daryl Evans

18 January 2021

Melanomacrophage centres (MMCs) are aggregates of macrophages accumulating various pigments. They have been proposed as an indicator of fish immune response. Blood flukes are common parasites in farmed fish. Two cohorts of wild Southern Bluefin Tuna...

(This article belongs to the Special Issue Fish Parasites and Immunology)
  • Review
  • Open Access
24 Citations
7,402 Views
14 Pages

18 January 2021

Arthropod-borne viral diseases (arboviruses) are a public-health concern in many regions of the world, including Thailand. This review describes the potential vectors and important human and/or veterinary arboviruses in Thailand. The medically import...

  • Article
  • Open Access
18 Citations
5,877 Views
15 Pages

Distribution and Genetic Diversity of Aedes aegypti Subspecies across the Sahelian Belt in Sudan

  • Sara Abdelrahman Abuelmaali,
  • Jamsari Amirul Firdaus Jamaluddin,
  • Kheder Noaman,
  • Mushal Allam,
  • Hind Mohammad Abushama,
  • Dia Eldin Elnaiem,
  • Intan Haslina Ishak,
  • Mustafa Fadzil Farid Wajidi,
  • Zairi Jaal and
  • Nur Faeza Abu Kassim

17 January 2021

Aedes aegypti is the most important arboviral disease vector worldwide. In Africa, it exists as two morphologically distinct forms, often referred to as subspecies, Aaa and Aaf. There is a dearth of information on the distribution and genetic diversi...

(This article belongs to the Special Issue Hemorrhagic Fever Viruses)
  • Case Report
  • Open Access
18 Citations
4,193 Views
12 Pages

Identification of the Source for Salmonella Contamination of Carcasses in a Large Pig Slaughterhouse

  • Hang Zeng,
  • Geertrui Rasschaert,
  • Lieven De Zutter,
  • Wesley Mattheus and
  • Koen De Reu

17 January 2021

To identify the major source of Salmonella contamination in a pig slaughterhouse, samples were collected from the clean and unclean area and Salmonella isolates were further typed. Carcasses entering the clean area showed a Salmonella contamination r...

  • Article
  • Open Access
14 Citations
3,658 Views
11 Pages

Management of Microbiological Contamination of the Water Network of a Newly Built Hospital Pavilion

  • Osvalda De Giglio,
  • Giusy Diella,
  • Marco Lopuzzo,
  • Francesco Triggiano,
  • Carla Calia,
  • Chrysovalentinos Pousis,
  • Fabrizio Fasano,
  • Giuseppe Calabrese,
  • Vincenza Rafaschieri and
  • Maria Teresa Montagna
  • + 8 authors

16 January 2021

The good installation, as well as commissioning plan, of a water network is a crucial step in reducing the risk of waterborne diseases. The aim of this study was to monitor the microbiological quality of water from a newly built pavilion before it co...

(This article belongs to the Section Waterborne/Foodborne/Airborne Pathogens)
  • Review
  • Open Access
29 Citations
8,688 Views
33 Pages

Epidemiology, Biotic Interactions and Biological Control of Armillarioids in the Northern Hemisphere

  • Orsolya Kedves,
  • Danish Shahab,
  • Simang Champramary,
  • Liqiong Chen,
  • Boris Indic,
  • Bettina Bóka,
  • Viktor Dávid Nagy,
  • Csaba Vágvölgyi,
  • László Kredics and
  • György Sipos

16 January 2021

Armillarioids, including the genera Armillaria, Desarmillaria and Guyanagaster, represent white-rot specific fungal saprotrophs with soilborne pathogenic potentials on woody hosts. They propagate in the soil by root-like rhizomorphs, connecting betwe...

  • Review
  • Open Access
29 Citations
7,188 Views
24 Pages

Emerging and Neglected Viruses of Zoonotic Importance in Croatia

  • Tatjana Vilibic-Cavlek,
  • Ljubo Barbic,
  • Anna Mrzljak,
  • Dragan Brnic,
  • Ana Klobucar,
  • Maja Ilic,
  • Natasa Janev-Holcer,
  • Maja Bogdanic,
  • Lorena Jemersic and
  • Vladimir Savic
  • + 9 authors

15 January 2021

Several arboviruses have emerged in Croatia in recent years. Tick-borne encephalitis is endemic in continental counties; however, new natural micro-foci have been detected. Two autochthonous dengue cases were reported in 2010. West Nile virus emerged...

(This article belongs to the Special Issue Emerging and Neglected Viruses and Zoonoses)
  • Article
  • Open Access
3 Citations
3,922 Views
16 Pages

Correlation between Pathogenic Determinants Associated with Clinically Isolated Non-Typhoidal Salmonella

  • Boimpoundi Eunice Flavie Ouali,
  • Tsyr-Huei Chiou,
  • Jenn-Wei Chen,
  • I-Chu Lin,
  • Ching-Chuan Liu,
  • Yu-Chung Chiang,
  • Tzong-Shiann Ho and
  • Hao-Ven Wang

15 January 2021

Non-typhoidal and Typhoidal Salmonella are bacterial pathogens source of worldwide and major disease burden. Virulent determinants of specific serovars belonging to non-typhoidal Salmonella have been extensively studied in different models, yet the p...

  • Article
  • Open Access
26 Citations
4,738 Views
10 Pages

Emergence of the New KPC-49 Variant Conferring an ESBL Phenotype with Resistance to Ceftazidime-Avibactam in the ST131-H30R1 Escherichia coli High-Risk Clone

  • Marta Hernández-García,
  • Javier Sánchez-López,
  • Laura Martínez-García,
  • Federico Becerra-Aparicio,
  • María Isabel Morosini,
  • Patricia Ruiz-Garbajosa and
  • Rafael Cantón

14 January 2021

We report the emergence of an isolate belonging to the sequence type (ST)131-Escherichia coli high-risk clone with ceftazidime-avibactam resistance recovered from a patient with bacteremia in 2019. Antimicrobial susceptibility was determined and whol...

  • Article
  • Open Access
12 Citations
4,460 Views
12 Pages

The Remarkable Metabolism of Vickermania ingenoplastis: Genomic Predictions

  • Fred R. Opperdoes,
  • Anzhelika Butenko,
  • Alexandra Zakharova,
  • Evgeny S. Gerasimov,
  • Sara L. Zimmer,
  • Julius Lukeš and
  • Vyacheslav Yurchenko

14 January 2021

A recently redescribed two-flagellar trypanosomatid Vickermania ingenoplastis is insensitive to the classical inhibitors of respiration and thrives under anaerobic conditions. Using genomic and transcriptomic data, we analyzed its genes of the core m...

(This article belongs to the Special Issue Kinetoplastid Phylogenomics and Evolution)
  • Article
  • Open Access
1 Citations
3,256 Views
10 Pages

14 January 2021

In silico analysis is a promising approach for understanding biological events in complex diseases. Herein we report on the innovative computational workflow allowed to highlight new direct interactions between human transcription factors (TFs) and a...

(This article belongs to the Special Issue Microbial Interactions during Infection)
  • Article
  • Open Access
14 Citations
6,172 Views
15 Pages

Enlisting the Ixodes scapularis Embryonic ISE6 Cell Line to Investigate the Neuronal Basis of Tick—Pathogen Interactions

  • Lourdes Mateos-Hernández,
  • Natália Pipová,
  • Eléonore Allain,
  • Céline Henry,
  • Clotilde Rouxel,
  • Anne-Claire Lagrée,
  • Nadia Haddad,
  • Henri-Jean Boulouis,
  • James J. Valdés and
  • Ladislav Šimo
  • + 3 authors

14 January 2021

Neuropeptides are small signaling molecules expressed in the tick central nervous system, i.e., the synganglion. The neuronal-like Ixodes scapularis embryonic cell line, ISE6, is an effective tool frequently used for examining tick–pathogen int...

(This article belongs to the Section Ticks)
  • Article
  • Open Access
20 Citations
5,512 Views
22 Pages

An Integrated Approach to Identify New Anti-Filarial Leads to Treat River Blindness, a Neglected Tropical Disease

  • Rahul Tyagi,
  • Christina A. Bulman,
  • Fidelis Cho-Ngwa,
  • Chelsea Fischer,
  • Chris Marcellino,
  • Michelle R. Arkin,
  • James H. McKerrow,
  • Case W. McNamara,
  • Matthew Mahoney and
  • Makedonka Mitreva
  • + 5 authors

14 January 2021

Filarial worms cause multiple debilitating diseases in millions of people worldwide, including river blindness. Currently available drugs reduce transmission by killing larvae (microfilariae), but there are no effective cures targeting the adult para...

(This article belongs to the Special Issue Onchocerciasis and River Epilepsy)
  • Article
  • Open Access
19 Citations
7,566 Views
21 Pages

Development of a Multiplex Real-Time PCR Assay for Predicting Macrolide and Tetracycline Resistance Associated with Bacterial Pathogens of Bovine Respiratory Disease

  • Enakshy Dutta,
  • John Dustin Loy,
  • Caitlyn A. Deal,
  • Emily L. Wynn,
  • Michael L. Clawson,
  • Jennifer Clarke and
  • Bing Wang

13 January 2021

Antimicrobial resistance (AMR) in bovine respiratory disease (BRD) is an emerging concern that may threaten both animal and public health. Rapid and accurate detection of AMR is essential for prudent drug therapy selection during BRD outbreaks. This...

(This article belongs to the Special Issue Detection and Characterization of Drug-Resistant Organisms)
  • Article
  • Open Access
15 Citations
4,268 Views
16 Pages

Genetic Diversity and Distribution of Virulence-Associated Genes in Y. enterocolitica and Y. enterocolitica-Like Isolates from Humans and Animals in Poland

  • Katarzyna Morka,
  • Ewa Wałecka-Zacharska,
  • Justyna Schubert,
  • Bartłomiej Dudek,
  • Anna Woźniak-Biel,
  • Maciej Kuczkowski,
  • Alina Wieliczko,
  • Jarosław Bystroń,
  • Jacek Bania and
  • Gabriela Bugla-Płoskońska

13 January 2021

Yersinia enterocolitica, widespread within domestic and wild-living animals, is a foodborne pathogen causing yersiniosis. The goal of this study was to assess a genetic similarity of Y. enterocolitica and Y. enterocolitica-like strains isolated from...

  • Article
  • Open Access
12 Citations
3,852 Views
15 Pages

Contamination Sources and Transmission Routes for Campylobacter on (Mixed) Broiler Farms in Belgium, and Comparison of the Gut Microbiota of Flocks Colonized and Uncolonized with Campylobacter

  • Karolien Hertogs,
  • Annelies Haegeman,
  • Dries Schaumont,
  • Philippe Gelaude,
  • Lieven De Zutter,
  • Jeroen Dewulf,
  • Marc Heyndrickx and
  • Geertrui Rasschaert

13 January 2021

Biosecurity seems to be the most promising tool for Campylobacter control on poultry farms. A longitudinal molecular epidemiological study was performed during two production cycles, in which the broilers, the poultry house, and the environment of 10...

  • Article
  • Open Access
9 Citations
3,635 Views
7 Pages

Lower Levels of Transaminases but Higher Levels of Serum Creatinine in Patients with Acute Hepatitis E in Comparison to Patients with Hepatitis A

  • Thomas Theo Brehm,
  • Omid Mazaheri,
  • Thomas Horvatits,
  • Marc Lütgehetmann,
  • Julian Schulze zur Wiesch,
  • Ansgar W. Lohse,
  • Susanne Polywka and
  • Sven Pischke

12 January 2021

In patients with hepatitis E virus (HEV) infections, extrahepatic, particularly renal and hematological manifestations, are increasingly reported in the medical literature but have never been studied compared to a control cohort. We retrospectively a...

  • Article
  • Open Access
12 Citations
4,750 Views
15 Pages

Influence of N-glycosylation on Expression and Function of Pseudorabies Virus Glycoprotein gB

  • Melina Vallbracht,
  • Barbara G. Klupp and
  • Thomas C. Mettenleiter

12 January 2021

Envelope glycoprotein (g)B is conserved throughout the Herpesviridae and mediates fusion of the viral envelope with cellular membranes for infectious entry and spread. Like all viral envelope fusion proteins, gB is modified by asparagine (N)-linked g...

(This article belongs to the Special Issue Pseudorabies Virus Infections)
  • Article
  • Open Access
44 Citations
4,877 Views
11 Pages

Psychophysical Evaluation of the Olfactory Function: European Multicenter Study on 774 COVID-19 Patients

  • Luigi Angelo Vaira,
  • Jerome R. Lechien,
  • Mohamad Khalife,
  • Marzia Petrocelli,
  • Stephane Hans,
  • Lea Distinguin,
  • Giovanni Salzano,
  • Marco Cucurullo,
  • Piero Doneddu and
  • Sven Saussez
  • + 5 authors

12 January 2021

Background: The objective evaluation of the olfactory function of coronavirus disease 2019 patients is difficult because of logistical and operator-safety problems. For this reason, in the literature, the data obtained from psychophysical tests are f...

(This article belongs to the Collection SARS-CoV Infections)
  • Communication
  • Open Access
19 Citations
8,789 Views
9 Pages

12 January 2021

Understanding the plant microbiome is a key for plant health and controlling pathogens. Recent studies have shown that plants are responsive towards natural and synthetic sound vibration (SV) by perception and signal transduction, which resulted in r...

(This article belongs to the Special Issue Biological Control of Phytopathogens: Mechanisms and Applications)
  • Communication
  • Open Access
7 Citations
2,959 Views
6 Pages

11 January 2021

Human herpesvirus 6A (HHV-6A) is a common virus that has important immunomodulatory effects. Dendritic cells (DC) are key players in innate and adaptive immunity and are implicated in the pathogenesis of many human diseases, including infections. (1)...

(This article belongs to the Section Human Pathogens)
  • Article
  • Open Access
46 Citations
4,786 Views
9 Pages

Systemic Inflammatory Index Is a Novel Predictor of Intubation Requirement and Mortality after SARS-CoV-2 Infection

  • Sajjad Muhammad,
  • Igor Fischer,
  • Soheil Naderi,
  • Morteza Faghih Jouibari,
  • Sheikhrezaei Abdolreza,
  • Ehsan Karimialavijeh,
  • Sara Aslzadeh,
  • Mahsa Mashayekhi,
  • Mohaddeseh Zojaji and
  • Daniel Hänggi
  • + 1 author

11 January 2021

Coronavirus disease 2019 (COVID-19), with an increasing number of deaths worldwide, has created a tragic global health and economic emergency. The disease, caused by severe acute respiratory syndrome coronavirus 2019 (SARS-CoV-19), is a multi-system...

(This article belongs to the Section Human Pathogens)
  • Article
  • Open Access
13 Citations
4,003 Views
15 Pages

11 January 2021

Hepatocellular carcinoma (HCC) is one of the world’s most widely recognized malignant tumors that accounts for 90% of all the primary liver cancers and is a major cause of death from cancer, representing half a million deaths per year. Obesity...

(This article belongs to the Special Issue Inflammation and Gastrointestinal/Hepatobiliary Cancers)
  • Article
  • Open Access
3 Citations
4,610 Views
10 Pages

Emerging Infectious Diseases in Pregnant Women in a Non-Endemic Area: Almost One Out of Four Is at Risk

  • Giulia Modi,
  • Beatrice Borchi,
  • Susanna Giaché,
  • Irene Campolmi,
  • Michele Trotta,
  • Mariarosaria Di Tommaso,
  • Noemi Strambi,
  • Alessandro Bartoloni and
  • Lorenzo Zammarchi

10 January 2021

We report the results of a targeted testing strategy for five emerging infectious diseases (Chagas disease, human T-lymphotropic virus 1 infection, malaria, schistosomiasis, and Zika virus infection) in pregnant women accessing an Italian referral ce...

  • Article
  • Open Access
18 Citations
4,778 Views
7 Pages

The Vector-Borne Zoonotic Nematode Thelazia callipaeda in the Eastern Part of Europe, with a Clinical Case Report in a Dog in Poland

  • Leszek Rolbiecki,
  • Joanna N. Izdebska,
  • Marta Franke,
  • Lech Iliszko and
  • Sławomira Fryderyk

Thelazia callipaeda is a zoonotic nematode transmitted by drosophilid flies. It causes ocular thelaziosis, a disease of carnivores, such as dogs, cats, and foxes, and also humans. The parasite has thus far been observed in various areas of Eurasia, i...

(This article belongs to the Special Issue Parasitic Diseases of Domestic, Wild, and Exotic Animals)
  • Article
  • Open Access
7 Citations
4,319 Views
16 Pages

The interactions between Drosophila melanogaster and the parasitoid wasps that infect Drosophila species provide an important model for understanding host–parasite relationships. Following parasitoid infection, D. melanogaster larvae mount a re...

  • Article
  • Open Access
6 Citations
4,680 Views
14 Pages

N-Glycosylation in Piroplasmids: Diversity within Simplicity

  • Monica Florin-Christensen,
  • Anabel E. Rodriguez,
  • Carlos E. Suárez,
  • Massaro W. Ueti,
  • Fernando O. Delgado,
  • Ignacio Echaide and
  • Leonhard Schnittger

N-glycosylation has remained mostly unexplored in Piroplasmida, an order of tick-transmitted pathogens of veterinary and medical relevance. Analysis of 11 piroplasmid genomes revealed three distinct scenarios regarding N-glycosylation: Babesia sensu...

(This article belongs to the Special Issue Bovine Babesiosis)
  • Article
  • Open Access
16 Citations
5,859 Views
8 Pages

Canine Distemper Outbreak by Natural Infection in a Group of Vaccinated Maned Wolves in Captivity

  • Vicente Vergara-Wilson,
  • Ezequiel Hidalgo-Hermoso,
  • Carlos R. Sanchez,
  • María J. Abarca,
  • Carlos Navarro,
  • Sebastian Celis-Diez,
  • Pilar Soto-Guerrero,
  • Nataly Diaz-Ayala,
  • Martin Zordan and
  • Javier Cabello-Stom
  • + 1 author

Canine distemper virus (CDV) is one of the most significant infectious disease threats to the health and conservation of free-ranging and captive wild carnivores. CDV vaccination using recombinant canarypox-based vaccines has been recommended for man...

(This article belongs to the Special Issue Canine Distemper Virus Infection)
  • Article
  • Open Access
28 Citations
5,754 Views
14 Pages

Exploring the Potential of Meyerozyma guilliermondii on Physiological Performances and Defense Response against Fusarium Crown Rot on Durum Wheat

  • Zayneb Kthiri,
  • Maissa Ben Jabeur,
  • Fadia Chairi,
  • Camilo López-Cristoffanini,
  • Marta López-Carbonell,
  • Maria Dolores Serret,
  • Jose Luis Araus,
  • Chahine Karmous and
  • Walid Hamada

Coating seeds with bio-control agents is a potentially effective approach to reduce the usage of pesticides and fertilizers applied and protect the natural environment. This study evaluated the effect of seed coating with Meyerozyma guilliermondii, s...

(This article belongs to the Special Issue Plant Resistance Induced by Microorganisms and Pathogens)
  • Article
  • Open Access
21 Citations
5,289 Views
20 Pages

Field information about viruses infecting crops is fundamental for understanding the severity of the effects they cause in plants. To determine the status of cucurbit viruses, surveys were conducted for three consecutive years (2016–2018) in di...

(This article belongs to the Section Viral Pathogens)
  • Article
  • Open Access
76 Citations
12,750 Views
21 Pages

Engineered Phage Endolysin Eliminates Gardnerella Biofilm without Damaging Beneficial Bacteria in Bacterial Vaginosis Ex Vivo

  • Christine Landlinger,
  • Lenka Tisakova,
  • Vera Oberbauer,
  • Timo Schwebs,
  • Abbas Muhammad,
  • Agnieszka Latka,
  • Leen Van Simaey,
  • Mario Vaneechoutte,
  • Alexander Guschin and
  • Lorenzo Corsini
  • + 3 authors

Bacterial vaginosis is characterized by an imbalance of the vaginal microbiome and a characteristic biofilm formed on the vaginal epithelium, which is initiated and dominated by Gardnerella bacteria, and is frequently refractory to antibiotic treatme...

(This article belongs to the Section Human Pathogens)
  • Communication
  • Open Access
15 Citations
4,362 Views
12 Pages

Extensive Phylogenetic Analysis of Piscine Orthoreovirus Genomic Sequences Shows the Robustness of Subgenotype Classification

  • Marcos Godoy,
  • Daniel A. Medina,
  • Rudy Suarez,
  • Sandro Valenzuela,
  • Jaime Romero,
  • Molly Kibenge,
  • Yingwei Wang and
  • Frederick Kibenge

Piscine orthoreovirus (PRV) belongs to the family Reoviridae and has been described mainly in association with salmonid infections. The genome of PRV consists of about 23,600 bp, with 10 segments of double-stranded RNA, classified as small (S1 to S4)...

(This article belongs to the Section Viral Pathogens)
  • Article
  • Open Access
24 Citations
5,448 Views
17 Pages

Triatomine Feeding Profiles and Trypanosoma cruzi Infection, Implications in Domestic and Sylvatic Transmission Cycles in Ecuador

  • Sofía Ocaña-Mayorga,
  • Juan José Bustillos,
  • Anita G. Villacís,
  • C. Miguel Pinto,
  • Simone Frédérique Brenière and
  • Mario J. Grijalva

Understanding the blood meal patterns of insects that are vectors of diseases is fundamental in unveiling transmission dynamics and developing strategies to impede or decrease human–vector contact. Chagas disease has a complex transmission cycl...

(This article belongs to the Special Issue Host-Pathogen Interaction Involved in Trypanosoma cruzi Infection)
  • Article
  • Open Access
11 Citations
6,171 Views
30 Pages

Equine herpesvirus 1 (EHV-1) affects horses worldwide and causes respiratory disease, abortions, and equine herpesvirus myeloencephalopathy (EHM). Following infection, a cell-associated viremia is established in the peripheral blood mononuclear cells...

(This article belongs to the Special Issue Equine Herpesviruses)
  • Review
  • Open Access
18 Citations
4,256 Views
11 Pages

Chronic hepatitis C (CHC) is a major cause of hepatocellular carcinoma (HCC) worldwide. While directly acting antiviral (DAA) drugs are now able to cure virtually all hepatitis C virus (HCV) infections, even in subjects with advanced liver disease, w...

(This article belongs to the Special Issue Hepatitis C Virus: Remaining Challenges)
  • Article
  • Open Access
33 Citations
7,105 Views
12 Pages

Whole-Genome Sequencing Analysis of Salmonella Enterica Serotype Enteritidis Isolated from Poultry Sources in South Korea, 2010–2017

  • Ji-Yeon Hyeon,
  • Shaoting Li,
  • David A. Mann,
  • Shaokang Zhang,
  • Kyu-Jik Kim,
  • Dong-Hun Lee,
  • Xiangyu Deng and
  • Chang-Seon Song

Salmonella enterica subsp. enterica serotype Enteritidis (SE) is recognized as a major cause of human salmonellosis worldwide, and most human salmonellosis is due to the consumption of contaminated poultry meats and poultry byproducts. Whole-genome s...

  • Article
  • Open Access
9 Citations
4,040 Views
17 Pages

Xylella fastidiosa is a xylem-limited bacterium phylogenetically related to the xanthomonads, with an unusually large and diversified range of plant hosts. To ascertain the origin of its peculiarities, its pan-genome was scanned to identify the genes...

(This article belongs to the Special Issue Progress on Understanding and Management of Xylella fastidiosa Infections)
  • Article
  • Open Access
5 Citations
3,577 Views
16 Pages

Can Previous Associations of Single Nucleotide Polymorphisms in the TLR2, NOD1, CXCR5, and IL10 Genes in the Susceptibility to and Severity of Chlamydia trachomatis Infections Be Confirmed?

  • Jelmer B. Jukema,
  • Bernice M. Hoenderboom,
  • Birgit H. B. van Benthem,
  • Marianne A. B. van der Sande,
  • Henry J. C. de Vries,
  • Christian J. P. A. Hoebe,
  • Nicole H. T. M. Dukers-Muijrers,
  • Caroline J. Bax,
  • Servaas A. Morré and
  • Sander Ouburg

Clear inter-individual differences exist in the response to C. trachomatis (CT) infections and reproductive tract complications in women. Host genetic variation like single nucleotide polymorphisms (SNPs) have been associated with differences in resp...

(This article belongs to the Special Issue Chlamydia trachomatis Infections)
  • Article
  • Open Access
14 Citations
2,892 Views
6 Pages

Porcine Gammaherpesviruses in Italian Commercial Swine Population: Frequent but Harmless

  • Giovanni Franzo,
  • Michele Drigo,
  • Matteo Legnardi,
  • Laura Grassi,
  • Maria Luisa Menandro,
  • Daniela Pasotto,
  • Mattia Cecchinato and
  • Claudia Maria Tucciarone

Differently from alpha- and betaherpesviruses affecting swine, interest in the recently discovered Suid gammaherpesvirus 3, Suid gammaherpesvirus 4, and Suid gammaherpesvirus 5, also known as porcine lymphotropic herpesviruses (PLHV-1, PLHV-2, and PL...

(This article belongs to the Section Animal Pathogens)
  • Review
  • Open Access
53 Citations
14,632 Views
20 Pages

Systematic Review of Wolbachia Symbiont Detection in Mosquitoes: An Entangled Topic about Methodological Power and True Symbiosis

  • Luísa Maria Inácio da Silva,
  • Filipe Zimmer Dezordi,
  • Marcelo Henrique Santos Paiva and
  • Gabriel Luz Wallau

Wolbachia is an endosymbiotic bacterium that naturally infects several arthropods and nematode species. Wolbachia gained particular attention due to its impact on their host fitness and the capacity of specific Wolbachia strains in reducing pathogen...

(This article belongs to the Section Animal Pathogens)
  • Communication
  • Open Access
6 Citations
2,613 Views
6 Pages

A 2-Year Longitudinal Seroepidemiological Evaluation of Toxoplasma gondii Antibodies in a Cohort of Autochthonous Sheep from Central Portugal

  • Daniela Almeida,
  • João Quirino,
  • Patrícia Ferreira Barradas,
  • Priscilla Gomes da Silva,
  • Maria Pereira,
  • Rita Cruz,
  • Carla Santos,
  • Ana Cristina Mega,
  • Fernando Esteves and
  • João R. Mesquita
  • + 4 authors

(1) Background: Toxoplasma gondii is an important zoonosis and one of the major causes of abortion in sheep worldwide. (2) Methods: We performed a 2-year longitudinal serological anti-T. gondii IgG screening on a cohort of a spatially confined popula...

(This article belongs to the Section Human Pathogens)
  • Article
  • Open Access
11 Citations
4,213 Views
9 Pages

Tick-borne infectious diseases caused by obligate intracellular bacteria of the genus Rickettsia are a growing global problem to human and animal health. Surveillance of these pathogens at the wildlife interface is critical to informing public health...

(This article belongs to the Collection Updates on Rickettsia and Coxiella)
  • Review
  • Open Access
16 Citations
5,742 Views
17 Pages

Nanoparticles as Vaccines to Prevent Arbovirus Infection: A Long Road Ahead

  • Gabriel Augusto Pires de Souza,
  • Raíssa Prado Rocha,
  • Ricardo Lemes Gonçalves,
  • Cyntia Silva Ferreira,
  • Breno de Mello Silva,
  • Renato Fróes Goulart de Castro,
  • João Francisco Vitório Rodrigues,
  • João Carlos Vilela Vieira Júnior,
  • Luiz Cosme Cotta Malaquias and
  • Luiz Felipe Leomil Coelho
  • + 1 author

Arthropod-borne viruses (arboviruses) are a significant public health problem worldwide. Vaccination is considered one of the most effective ways to control arbovirus diseases in the human population. Nanoparticles have been widely explored as new va...

(This article belongs to the Special Issue Diagnostics and Surveillance of Arboviral Diseases)
  • Article
  • Open Access
5 Citations
3,918 Views
13 Pages

Bloodstream Infections Caused by Extended-Spectrum Beta-Lactamase-Producing Escherichia coli in Patients with Liver Cirrhosis

  • Wen-Chi Chen,
  • Chih-Hsin Hung,
  • Yao-Shen Chen,
  • Jin-Shiung Cheng,
  • Susan Shin-Jung Lee,
  • Fan-Chen Tseng,
  • Ming-Fang Cheng and
  • Jiun-Ling Wang

Background: This study aimed to investigate the frequency of sequence type (ST) 131 strains and outcome of cirrhotic patients with bloodstream infections (BSIs) caused by extended-spectrum beta-lactamase-producing Escherichiacoli (ESBLEC) and non-ext...

(This article belongs to the Section Bacterial Pathogens)

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Pathogens - ISSN 2076-0817