Insects 2012, 3(2), 511-531; doi:10.3390/insects3020511
Review

New Insights into Control of Arbovirus Replication and Spread by Insect RNA Interference Pathways

Received: 1 April 2012; in revised form: 11 May 2012 / Accepted: 16 May 2012 / Published: 29 May 2012
(This article belongs to the Special Issue Insect Immunity)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Arthropod-borne (arbo) viruses are transmitted by vectors, such as mosquitoes, to susceptible vertebrates. Recent research has shown that arbovirus replication and spread in mosquitoes is not passively tolerated but induces host responses to control these pathogens. Small RNA-mediated host responses are key players among these antiviral immune strategies. Studies into one such small RNA-mediated antiviral response, the exogenous RNA interference (RNAi) pathway, have generated a wealth of information on the functions of this mechanism and the enzymes which mediate antiviral activities. However, other small RNA-mediated host responses may also be involved in modulating antiviral activity. The aim of this review is to summarize recent research into the nature of small RNA-mediated antiviral responses in mosquitoes and to discuss future directions for this relatively new area of research.
Keywords: arbovirus; mosquito; small RNAs; RNA interference; RNAi; RNA silencing; antiviral immunity
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MDPI and ACS Style

Donald, C.L.; Kohl, A.; Schnettler, E. New Insights into Control of Arbovirus Replication and Spread by Insect RNA Interference Pathways. Insects 2012, 3, 511-531.

AMA Style

Donald CL, Kohl A, Schnettler E. New Insights into Control of Arbovirus Replication and Spread by Insect RNA Interference Pathways. Insects. 2012; 3(2):511-531.

Chicago/Turabian Style

Donald, Claire L.; Kohl, Alain; Schnettler, Esther. 2012. "New Insights into Control of Arbovirus Replication and Spread by Insect RNA Interference Pathways." Insects 3, no. 2: 511-531.

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