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Insects 2012, 3(1), 324-338; doi:10.3390/insects3010324

Molecular Mechanisms of Transcription Activation by Juvenile Hormone: A Critical Role for bHLH-PAS and Nuclear Receptor Proteins

1
Department of Biology, Fordham University, Bronx, NY 10458, USA
2
Center for Cancer, Genetic Diseases, and Gene Regulation, Fordham University, Bronx, NY 10458, USA
*
Author to whom correspondence should be addressed.
Received: 21 February 2012 / Revised: 15 March 2012 / Accepted: 16 March 2012 / Published: 22 March 2012
(This article belongs to the Special Issue Feature Papers 2012)
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Abstract

Juvenile hormone (JH) is responsible for controlling many biological processes. In several insect species JH has been implicated as a key regulator of developmental timing, preventing the premature onset of metamorphosis during larval growth periods. However, the molecular basis of JH action is not well-understood. In this review, we highlight recent advances which demonstrate the importance of transcription factors from the bHLH-PAS and nuclear receptor families in mediating the response to JH.
Keywords: Drosophila melanogaster; juvenile hormone; nuclear receptor; bHLH-PAS; methoprene-tolerant; germ cell-expressed Drosophila melanogaster; juvenile hormone; nuclear receptor; bHLH-PAS; methoprene-tolerant; germ cell-expressed
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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Bernardo, T.J.; Dubrovsky, E.B. Molecular Mechanisms of Transcription Activation by Juvenile Hormone: A Critical Role for bHLH-PAS and Nuclear Receptor Proteins. Insects 2012, 3, 324-338.

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