J. Pers. Med. 2013, 3(4), 306-325; doi:10.3390/jpm3040306
Opinion

The Need for Clinical Decision Support Integrated with the Electronic Health Record for the Clinical Application of Whole Genome Sequencing Information

1 Program in Personalized Health Care, University of Utah, 15 North 2030 East, EIHG Room 2110, Salt Lake City, UT 84112, USA 2 Department of Biomedical Informatics, University of Utah, 26 South 2000 East, Room 5775 HSEB, Salt Lake City, UT 84112, USA
* Author to whom correspondence should be addressed.
Received: 21 October 2013; in revised form: 23 November 2013 / Accepted: 12 December 2013 / Published: 18 December 2013
(This article belongs to the Special Issue Feature Paper 2013)
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Abstract: Whole genome sequencing (WGS) is rapidly approaching widespread clinical application. Technology advancements over the past decade, since the first human genome was decoded, have made it feasible to use WGS for clinical care. Future advancements will likely drive down the price to the point wherein WGS is routinely available for care. However, were this to happen today, most of the genetic information available to guide clinical care would go unused due to the complexity of genetics, limited physician proficiency in genetics, and lack of genetics professionals in the clinical workforce. Furthermore, these limitations are unlikely to change in the future. As such, the use of clinical decision support (CDS) to guide genome-guided clinical decision-making is imperative. In this manuscript, we describe the barriers to widespread clinical application of WGS information, describe how CDS can be an important tool for overcoming these barriers, and provide clinical examples of how genome-enabled CDS can be used in the clinical setting.
Keywords: clinical decision support systems; medical genetics; genomics; genetic testing; electronic health records; health information technology; personalized medicine

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MDPI and ACS Style

Welch, B.M.; Kawamoto, K. The Need for Clinical Decision Support Integrated with the Electronic Health Record for the Clinical Application of Whole Genome Sequencing Information. J. Pers. Med. 2013, 3, 306-325.

AMA Style

Welch BM, Kawamoto K. The Need for Clinical Decision Support Integrated with the Electronic Health Record for the Clinical Application of Whole Genome Sequencing Information. Journal of Personalized Medicine. 2013; 3(4):306-325.

Chicago/Turabian Style

Welch, Brandon M.; Kawamoto, Kensaku. 2013. "The Need for Clinical Decision Support Integrated with the Electronic Health Record for the Clinical Application of Whole Genome Sequencing Information." J. Pers. Med. 3, no. 4: 306-325.

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