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Diagnostics 2015, 5(4), 475-486; doi:10.3390/diagnostics5040475

Beyond Screening: Can the Mini-Mental State Examination be Used as an Exclusion Tool in a Memory Clinic?

Memory, Aging and Cognition Center, Department of Pharmacology, National University Health System, Singapore 117600, Singapore
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Academic Editor: Eef Hogervorst
Received: 5 October 2015 / Revised: 29 October 2015 / Accepted: 29 October 2015 / Published: 4 November 2015
(This article belongs to the Special Issue Early Dementia Screening and Treatment)
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Abstract

This study explores whether the Mini-Mental State Examination (MMSE) could reliably exclude definite dementia and dementia-free cases from requiring more extensive neuropsychological investigations in memory clinic settings in Singapore. Patients with memory complaints referred for possible dementia underwent the MMSE, followed by standardized neuropsychological and clinical assessments which led to a consensus diagnosis. MMSE cut-off points were derived stratified for education (less and equal/above primary level). Results show that after education stratification, using an optimal Positive Likelihood Ratio (PLR) and optimal Negative Likelihood Ratio (NLR), a higher percentage of patients were correctly identified as having dementia or dementia-free, with minimal misclassification rate. The finding suggests the MMSE can be used to exclude patients not requiring full neuropsychological assessments in a memory clinic. View Full-Text
Keywords: dementia; cognitive assessment; Mini-Mental State Examination; memory clinic dementia; cognitive assessment; Mini-Mental State Examination; memory clinic
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MDPI and ACS Style

Xu, X.; Chong, E.; Hilal, S.; Ikram, M.K.; Venketasubramanian, N.; Chen, C. Beyond Screening: Can the Mini-Mental State Examination be Used as an Exclusion Tool in a Memory Clinic? Diagnostics 2015, 5, 475-486.

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