Next Article in Journal
OFP1 Interaction with ATH1 Regulates Stem Growth, Flowering Time and Flower Basal Boundary Formation in Arabidopsis
Previous Article in Journal
An Integrated Approach for Identifying Molecular Subtypes in Human Colon Cancer Using Gene Expression Data
Article Menu
Issue 8 (August) cover image

Export Article

Open AccessArticle
Genes 2018, 9(8), 398;

Genome-Wide Characterization of DNA Demethylase Genes and Their Association with Salt Response in Pyrus

Institute of Pomology, Jiangsu Academy of Agricultural Sciences/Jiangsu Key Laboratory for Horticultural Crop Genetic Improvement, Nanjing 210014, China
Department of Plant Sciences, University of Tennessee, Knoxville, TN 37996, USA
Institute of Botany, Jiangsu Province and Chinese Academy of Sciences, Nanjing 210014, China
Authors to whom correspondence should be addressed.
Received: 13 July 2018 / Revised: 30 July 2018 / Accepted: 31 July 2018 / Published: 6 August 2018
(This article belongs to the Section Molecular Genetics and Genomics)
Full-Text   |   PDF [2730 KB, uploaded 8 August 2018]   |  


DNA methylation plays important roles in genome protection and the regulation of gene expression and it is associated with plants’ responses to environments. DNA demethylases are very important proteins in DNA methylation regulation. In this study, we performed genome-wide and deep analysis of putative demethylases (DMEs) in pear. Seven DME genes were found in the pear genome and were defined as PbDME1–7 based on their domain organization. Results were supported by the gene structural characteristics and phylogenetic analysis. The gene structure of the DME genes were relatively complex and the DME7 proteins didn’t contain the Perm_CXXC domain. The DME genes experienced a whole genome duplication event (WGD) that occurred in the ancestor genome of pear and apple before their divergence based on the Ks values. Expression results showed that high salinity stress could influence the expression level of DMEs and salt-responsive genes in Pyrus betulaefolia. Furthermore, the methylation levels of salt-responsive genes changed under salt stress treatment. Results suggested important roles of PbDME genes in response to salt stress and are useful for better understanding the complex functions of this DME genes, which will facilitate epigenetic studies in pear trees salt tolerance. View Full-Text
Keywords: Pyrus betulaefolia; demethylase genes; genome-wide; salt response Pyrus betulaefolia; demethylase genes; genome-wide; salt response

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Supplementary material


Share & Cite This Article

MDPI and ACS Style

Liu, C.; Li, H.; Lin, J.; Wang, Y.; Xu, X.; Cheng, Z.-M.M.; Chang, Y. Genome-Wide Characterization of DNA Demethylase Genes and Their Association with Salt Response in Pyrus. Genes 2018, 9, 398.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Genes EISSN 2073-4425 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top