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Genes 2018, 9(3), 134; doi:10.3390/genes9030134

The Unforeseen Non-Coding RNAs in Head and Neck Cancer

Department of Prosthetic Dentistry and Dental Materials, Division Dental Propaedeutic, Aesthetic, “IuliuHatieganu” University of Medicine and Pharmacy, Cluj-Napoca, 23 Marinescu Street, 40015 Cluj-Napoca, Romania
MEDFUTURE—Research Center for Advanced Medicine, University of Medicine and Pharmacy Iuliu-Hatieganu, 23 Marinescu Street, 40015 Cluj-Napoca, Romania
Department of Medical Biology, Medical University Plovdiv, BulVasilAprilov 15-А, Plovdiv 4002, Bulgaria
Technological Center for Emergency Medicine, BulVasilAprilov 15-А, Plovdiv 4002, Bulgaria
Research Center for Functional Genomics and Translational Medicine, “IuliuHatieganu” University of Medicine and Pharmacy, 23 Marinescu Street, 40015 Cluj-Napoca, Romania
Department of Functional Genomics and Experimental Pathology, The Oncology Institute “Prof. Dr. Ion Chiricuta”, Republicii 34 Street, 400015 Cluj-Napoca, Romania
Author to whom correspondence should be addressed.
Received: 31 January 2018 / Revised: 21 February 2018 / Accepted: 22 February 2018 / Published: 1 March 2018
(This article belongs to the Special Issue Non-coding RNAs)
View Full-Text   |   Download PDF [4970 KB, uploaded 1 March 2018]   |  


Previously ignored non-coding RNAs (ncRNAs) have become the subject of many studies. However, there is an imbalance in the amount of consideration that ncRNAs are receiving. Some transcripts such as microRNAs (miRNAs) or small interfering RNAs (siRNAs) have gained much attention, but it is necessary to investigate other “pieces of the RNA puzzle”. These can offer a more complete view over normal and pathological cell behavior. The other ncRNA species are less studied, either due to their recent discovery, such as stable intronic sequence RNA (sisRNA), YRNA, miRNA-offset RNAs (moRNA), telomerase RNA component (TERC), natural antisense transcript (NAT), transcribed ultraconserved regions (T-UCR), and pseudogene transcript, or because they are still largely seen as non-coding transcripts with no relevance to pathogenesis. Moreover, some are still considered housekeeping RNAs, for instance small nucleolar RNAs (snoRNAs) and TERC. Our review summarizes the biogenesis, mechanism of action and potential role of less known ncRNAs in head and neck cancer, with a particular focus on the installment and progress for this particular cancer type. View Full-Text
Keywords: head and neck cancer; rare non-coding RNAs; biological mechanisms head and neck cancer; rare non-coding RNAs; biological mechanisms

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Irimie, A.I.; Zimta, A.-A.; Ciocan, C.; Mehterov, N.; Dudea, D.; Braicu, C.; Berindan-Neagoe, I. The Unforeseen Non-Coding RNAs in Head and Neck Cancer. Genes 2018, 9, 134.

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