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Genes 2017, 8(4), 120; doi:10.3390/genes8040120

MYC, Cell Competition, and Cell Death in Cancer: The Inseparable Triad

Department of Pharmacy and Biotechnology, University of Bologna, Via Selmi 3, 40126 Bologna, Italy
Co-first authors.
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Author to whom correspondence should be addressed.
Academic Editor: Daitoku Sakamuro
Received: 13 March 2017 / Revised: 9 April 2017 / Accepted: 12 April 2017 / Published: 17 April 2017
(This article belongs to the Special Issue MYC Networks)
View Full-Text   |   Download PDF [1218 KB, uploaded 17 April 2017]   |  

Abstract

Deregulation of MYC family proteins in cancer is associated with a global reprogramming of gene expression, ultimately promoting glycolytic pathways, cell growth, and proliferation. It is well known that MYC upregulation triggers cell-autonomous apoptosis in normal tissues, while frankly malignant cells develop resistance to apoptotic stimuli, partly resulting from MYC addiction. As well as inducing cell-autonomous apoptosis, MYC upregulation is able to trigger non cell-autonomous apoptotic death through an evolutionarily conserved mechanism known as “cell competition”. With regard to this intimate and dual relationship between MYC and cell death, recent evidence obtained in Drosophila models of cancer has revealed that, in early tumourigenesis, MYC upregulation guides the clonal expansion of mutant cells, while the surrounding tissue undergoes non-cell autonomous death. Apoptosis inhibition in this context was shown to restrain tumour growth and to restore a wild-type phenotype. This suggests that cell-autonomous and non cell-autonomous apoptosis dependent on MYC upregulation may shape tumour growth in different ways, soliciting the need to reconsider the role of cell death in cancer in the light of this new level of complexity. Here we review recent literature about MYC and cell competition obtained in Drosophila, with a particular emphasis on the relevance of cell death to cell competition and, more generally, to cancer. Possible implications of these findings for the understanding of mammalian cancers are also discussed. View Full-Text
Keywords: MYC; cell competition; cancer; apoptosis; Drosophila MYC; cell competition; cancer; apoptosis; Drosophila
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Di Giacomo, S.; Sollazzo, M.; Paglia, S.; Grifoni, D. MYC, Cell Competition, and Cell Death in Cancer: The Inseparable Triad. Genes 2017, 8, 120.

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