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Genes 2017, 8(4), 123; doi:10.3390/genes8040123

c-MYC—Making Liver Sick: Role of c-MYC in Hepatic Cell Function, Homeostasis and Disease

1
Department of Immunology, Complutense University School of Medicine, Plaza Ramón y Cajal s/n, Madrid 28040, Spain
2
12 de Octubre Health Research Institute (imas12), Madrid 28041, Spain
3
Department of Internal Medicine III, University Hospital RWTH, Aachen 52074, Germany
4
Department of Animal Physiology II, Faculty of Biology, Complutense University of Madrid (UCM), José Antonio Novais 12, Madrid 28040, Spain
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Academic Editor: Daitoku Sakamuro
Received: 7 February 2017 / Revised: 30 March 2017 / Accepted: 12 April 2017 / Published: 19 April 2017
(This article belongs to the Special Issue MYC Networks)
View Full-Text   |   Download PDF [593 KB, uploaded 19 April 2017]   |  

Abstract

Over 35 years ago, c-MYC, a highly pleiotropic transcription factor that regulates hepatic cell function, was identified. In recent years, a considerable increment in the number of publications has significantly shifted the way that the c-MYC function is perceived. Overexpression of c-MYC alters a wide range of roles including cell proliferation, growth, metabolism, DNA replication, cell cycle progression, cell adhesion and differentiation. The purpose of this review is to broaden the understanding of the general functions of c-MYC, to focus on c-MYC-driven pathogenesis in the liver, explain its mode of action under basal conditions and during disease, and discuss efforts to target c-MYC as a plausible therapy for liver disease. View Full-Text
Keywords: c-Myc Avian Myelocytomatosis Viral Oncogene Homolog; hepatocellular carcinoma; alcoholic liver disease; hepatoblastoma; hepatitis B virus; hepatitis C virus; Liver c-Myc Avian Myelocytomatosis Viral Oncogene Homolog; hepatocellular carcinoma; alcoholic liver disease; hepatoblastoma; hepatitis B virus; hepatitis C virus; Liver
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Zheng, K.; Cubero, F.J.; Nevzorova, Y.A. c-MYC—Making Liver Sick: Role of c-MYC in Hepatic Cell Function, Homeostasis and Disease. Genes 2017, 8, 123.

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