Next Article in Journal
Modeling and Targeting MYC Genes in Childhood Brain Tumors
Next Article in Special Issue
Anatomy of Mammalian Replication Domains
Previous Article in Journal
The Epigenetic Link between Prenatal Adverse Environments and Neurodevelopmental Disorders
Previous Article in Special Issue
Regulation of DNA Replication through Natural  Impediments in the Eukaryotic Genome
Article Menu

Export Article

Open AccessReview
Genes 2017, 8(3), 105; doi:10.3390/genes8030105

Roles of CDK and DDK in Genome Duplication and Maintenance: Meiotic Singularities

Genome Duplication and Maintenance Team, Institute of Genetics and Development of Rennes, CNRS UMR 6290, 2 av. du Pr. Léon Bernard, 35043 Rennes
*
Author to whom correspondence should be addressed.
Received: 21 February 2017 / Revised: 13 March 2017 / Accepted: 14 March 2017 / Published: 20 March 2017
(This article belongs to the Special Issue DNA Replication Controls)
View Full-Text   |   Download PDF [663 KB, uploaded 22 March 2017]   |  

Abstract

Cells reproduce using two types of divisions: mitosis, which generates two daughter cells each with the same genomic content as the mother cell, and meiosis, which reduces the number of chromosomes of the parent cell by half and gives rise to four gametes. The mechanisms that promote the proper progression of the mitotic and meiotic cycles are highly conserved and controlled. They require the activities of two types of serine-threonine kinases, the cyclin-dependent kinases (CDKs) and the Dbf4-dependent kinase (DDK). CDK and DDK are essential for genome duplication and maintenance in both mitotic and meiotic divisions. In this review, we aim to highlight how these kinases cooperate to orchestrate diverse processes during cellular reproduction, focusing on meiosis-specific adaptions of their regulation and functions in DNA metabolism.
View Full-Text
Keywords: cyclin-dependent kinase; Dbf4-dependent kinase; mitosis; meiosis; genome duplication; meiotic recombination; quantitative model cyclin-dependent kinase; Dbf4-dependent kinase; mitosis; meiosis; genome duplication; meiotic recombination; quantitative model
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Gómez-Escoda, B.; Wu, P.-Y.J. Roles of CDK and DDK in Genome Duplication and Maintenance: Meiotic Singularities
. Genes 2017, 8, 105.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Genes EISSN 2073-4425 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top