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Genes 2017, 8(4), 110; doi:10.3390/genes8040110

Anatomy of Mammalian Replication Domains

1
Department of Biochemistry and Proteomics, Graduate School of Medicine, Mie University, Tsu, Mie 514-8507, Japan
2
Laboratory of Molecular and Cellular Biology, Department of Life Sciences, Graduate School of Bioresources, Mie University, Tsu, Mie 514-8507, Japan
*
Authors to whom correspondence should be addressed.
Academic Editor: Eishi Noguchi
Received: 8 December 2016 / Revised: 22 March 2017 / Accepted: 24 March 2017 / Published: 28 March 2017
(This article belongs to the Special Issue DNA Replication Controls)
View Full-Text   |   Download PDF [1569 KB, uploaded 28 March 2017]   |  

Abstract

Genetic information is faithfully copied by DNA replication through many rounds of cell division. In mammals, DNA is replicated in Mb-sized chromosomal units called “replication domains.” While genome-wide maps in multiple cell types and disease states have uncovered both dynamic and static properties of replication domains, we are still in the process of understanding the mechanisms that give rise to these properties. A better understanding of the molecular basis of replication domain regulation will bring new insights into chromosome structure and function. View Full-Text
Keywords: DNA replication; mammalian chromosome; replication domain; replication foci; replication origin DNA replication; mammalian chromosome; replication domain; replication foci; replication origin
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Takebayashi, S.-I.; Ogata, M.; Okumura, K. Anatomy of Mammalian Replication Domains. Genes 2017, 8, 110.

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