Next Article in Journal
Differences in the Bacteriome of Smokeless Tobacco Products with Different Oral Carcinogenicity: Compositional and Predicted Functional Analysis
Next Article in Special Issue
The MYCN Protein in Health and Disease
Previous Article in Journal
Roles of CDK and DDK in Genome Duplication and Maintenance: Meiotic Singularities
Previous Article in Special Issue
c‐Myc‐Induced Survivin Is Essential for Promoting  the Notch‐Dependent T Cell Differentiation from  Hematopoietic Stem Cells
Article Menu
Issue 4 (April) cover image

Export Article

Open AccessReview
Genes 2017, 8(4), 107; doi:10.3390/genes8040107

Modeling and Targeting MYC Genes in Childhood Brain Tumors

Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Rudbeck Laboratory, Uppsala University, 751 85 Uppsala, Sweden
*
Author to whom correspondence should be addressed.
Academic Editor: Daitoku Sakamuro
Received: 2 February 2017 / Revised: 14 March 2017 / Accepted: 16 March 2017 / Published: 23 March 2017
(This article belongs to the Special Issue MYC Networks)
View Full-Text   |   Download PDF [1626 KB, uploaded 29 March 2017]   |  

Abstract

Brain tumors are the second most common group of childhood cancers, accounting for about 20%–25% of all pediatric tumors. Deregulated expression of the MYC family of transcription factors, particularly c-MYC and MYCN genes, has been found in many of these neoplasms, and their expression levels are often correlated with poor prognosis. Elevated c-MYC/MYCN initiates and drives tumorigenesis in many in vivo model systems of pediatric brain tumors. Therefore, inhibition of their oncogenic function is an attractive therapeutic target. In this review, we explore the roles of MYC oncoproteins and their molecular targets during the formation, maintenance, and recurrence of childhood brain tumors. We also briefly summarize recent progress in the development of therapeutic approaches for pharmacological inhibition of MYC activity in these tumors. View Full-Text
Keywords: MYC; oncogene; pediatric brain tumors; targeted therapy; medulloblastoma; glioma MYC; oncogene; pediatric brain tumors; targeted therapy; medulloblastoma; glioma
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Hutter, S.; Bolin, S.; Weishaupt, H.; Swartling, F.J. Modeling and Targeting MYC Genes in Childhood Brain Tumors. Genes 2017, 8, 107.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Genes EISSN 2073-4425 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top