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Genes 2017, 8(12), 366; doi:10.3390/genes8120366

Current Research on Non-Coding Ribonucleic Acid (RNA)

1
Department of Biostatistics, Vanderbilt University, Medical Center, Nashville, TN 37232, USA
2
Department of Molecular Physiology and Biophysics, Vanderbilt Genetics Institute, Vanderbilt University Medical School, Nashville, TN 37232, USA
3
Department of Biochemistry and Molecular Biology, McGovern Medical School at The University of Texas Health Science Center at Houston, Houston, TX 77030, USA
4
Key Laboratory of Resource Biology and Biotechnology in Western China, School of Life Sciences, Northwest University, Xi’an 710069, Shaanxi, China
5
Department of Internal Medicine, University of New Mexico, Albuquerque, NM 87102, USA
*
Author to whom correspondence should be addressed.
Received: 13 October 2017 / Revised: 16 November 2017 / Accepted: 21 November 2017 / Published: 5 December 2017
(This article belongs to the Special Issue Non-coding RNAs)
View Full-Text   |   Download PDF [1634 KB, uploaded 5 December 2017]   |  

Abstract

Non-coding ribonucleic acid (RNA) has without a doubt captured the interest of biomedical researchers. The ability to screen the entire human genome with high-throughput sequencing technology has greatly enhanced the identification, annotation and prediction of the functionality of non-coding RNAs. In this review, we discuss the current landscape of non-coding RNA research and quantitative analysis. Non-coding RNA will be categorized into two major groups by size: long non-coding RNAs and small RNAs. In long non-coding RNA, we discuss regular long non-coding RNA, pseudogenes and circular RNA. In small RNA, we discuss miRNA, transfer RNA, piwi-interacting RNA, small nucleolar RNA, small nuclear RNA, Y RNA, single recognition particle RNA, and 7SK RNA. We elaborate on the origin, detection method, and potential association with disease, putative functional mechanisms, and public resources for these non-coding RNAs. We aim to provide readers with a complete overview of non-coding RNAs and incite additional interest in non-coding RNA research. View Full-Text
Keywords: long non-coding RNA; small RNA; detection; functional mechanism; disease; resource long non-coding RNA; small RNA; detection; functional mechanism; disease; resource
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Wang, J.; Samuels, D.C.; Zhao, S.; Xiang, Y.; Zhao, Y.-Y.; Guo, Y. Current Research on Non-Coding Ribonucleic Acid (RNA). Genes 2017, 8, 366.

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