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Genes 2017, 8(12), 358; doi:10.3390/genes8120358

Phylogenetic Analysis of the SNORD116 Locus

1
Translational Biology, Medicine and Health Graduate Program, Virginia Tech, Blacksburg, VA 24061, USA
2
Department of Human Nutrition, Foods, and Exercise, Virginia Tech, Blacksburg, VA 24061, USA
*
Author to whom correspondence should be addressed.
Received: 31 October 2017 / Revised: 25 November 2017 / Accepted: 26 November 2017 / Published: 30 November 2017
(This article belongs to the Special Issue Non-coding RNAs)
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Abstract

The SNORD116 small nucleolar RNA locus (SNORD116@) is contained within the long noncoding RNA host gene SNHG14 on human chromosome 15q11-q13. The SNORD116 locus is a cluster of 28 or more small nucleolar (sno) RNAs; C/D box (SNORDs). Individual RNAs within the cluster are tandem, highly similar sequences, referred to as SNORD116-1, SNORD116-2, etc., with the entire set referred to as SNORD116@. There are also related SNORD116 loci on other chromosomes, and these additional loci are conserved among primates. Inherited chromosomal 15q11-q13 deletions, encompassing the SNORD116@ locus, are causative for the paternally-inherited/maternally-imprinted genetic condition, Prader–Willi syndrome (PWS). Using in silico tools, along with molecular-based and sequenced-based confirmation, phylogenetic analysis of the SNORD116@ locus was performed. The consensus sequence for the SNORD116@ snoRNAs from various species was determined both for all the SNORD116 snoRNAs, as well as those grouped using sequence and location according to a human grouping convention. The implications of these findings are put in perspective for studying SNORD116 in patients with inherited Prader–Willi syndrome, as well as model organisms. View Full-Text
Keywords: Prader–Willi Syndrome; snoRNA; phylogenetic analysis; imprinting Prader–Willi Syndrome; snoRNA; phylogenetic analysis; imprinting
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Kocher, M.A.; Good, D.J. Phylogenetic Analysis of the SNORD116 Locus. Genes 2017, 8, 358.

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