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Genes 2017, 8(10), 217; doi:10.3390/genes8100217

Alternative Splicing in Breast Cancer and the Potential Development of Therapeutic Tools

1
Centro de Investigaciones en Ciencias Microbiológicas, Instituto de Ciencias, Benemérita Universidad Autónoma de Puebla, Puebla CP 72570, Mexico
2
Centro de Investigación Biomédica de Oriente (CIBIOR), Instituto Mexicano del Seguro Social (IMSS), Metepec, Puebla CP 74360, Mexico
3
Centro Universitario de Vinculación, Dirección de Innovación y Transferencia de Conocimiento, Benemérita Universidad Autónoma de Puebla, Puebla CP 72570, Mexico
4
Edificio IC11, Ciudad Universitaria, Col. San Manuel, Puebla CP 72570, Mexico
Current address: Department of Microbiology and Infectious Diseases, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, QC J1E 4K8, Canada.
*
Author to whom correspondence should be addressed.
Academic Editor: Michael Ladomery
Received: 28 July 2017 / Revised: 22 August 2017 / Accepted: 22 August 2017 / Published: 5 October 2017
(This article belongs to the Special Issue Aberrant Pre-mRNA Splicing in Disease)
View Full-Text   |   Download PDF [1831 KB, uploaded 5 October 2017]   |  

Abstract

Alternative splicing is a key molecular mechanism now considered as a hallmark of cancer that has been associated with the expression of distinct isoforms during the onset and progression of the disease. The leading cause of cancer-related deaths in women worldwide is breast cancer, and even when the role of alternative splicing in this type of cancer has been established, the function of this mechanism in breast cancer biology is not completely decoded. In order to gain a comprehensive view of the role of alternative splicing in breast cancer biology and development, we summarize here recent findings regarding alternative splicing events that have been well documented for breast cancer evolution, considering its prognostic and therapeutic value. Moreover, we analyze how the response to endocrine and chemical therapies could be affected due to alternative splicing and differential expression of variant isoforms. With all this knowledge, it becomes clear that targeting alternative splicing represents an innovative approach for breast cancer therapeutics and the information derived from current studies could guide clinical decisions with a direct impact in the clinical advances for breast cancer patients nowadays. View Full-Text
Keywords: breast cancer; alternative splicing; prognosis; therapeutics; expression breast cancer; alternative splicing; prognosis; therapeutics; expression
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Martínez-Montiel, N.; Anaya-Ruiz, M.; Pérez-Santos, M.; Martínez-Contreras, R.D. Alternative Splicing in Breast Cancer and the Potential Development of Therapeutic Tools. Genes 2017, 8, 217.

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