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Genes 2016, 7(9), 64; doi:10.3390/genes7090064

Telomerase Regulation from Beginning to the End

1
Bloomfield Centre for Research in Aging, Lady Davis Institute for Medical Research, Jewish General Hospital, 3755 Côte Ste-Catherine Road, Montréal, QC H3T 1E2, Canada
2
Room M-29, Department of Anatomy and Cell Biology, McGill University, 3640 University Street, Montréal, QC H3A 0C7, Canada
3
Department of Experimental Medicine, McGill University, 1110 Pins Avenue West, Room 101, Montréal, QC H3A 1A3, Canada
*
Author to whom correspondence should be addressed.
Academic Editor: Gabriele Saretzki
Received: 6 July 2016 / Revised: 25 August 2016 / Accepted: 26 August 2016 / Published: 14 September 2016
(This article belongs to the Special Issue Telomerase Activity in Human Cells)
View Full-Text   |   Download PDF [3366 KB, uploaded 14 September 2016]   |  

Abstract

The vast body of literature regarding human telomere maintenance is a true testament to the importance of understanding telomere regulation in both normal and diseased states. In this review, our goal was simple: tell the telomerase story from the biogenesis of its parts to its maturity as a complex and function at its site of action, emphasizing new developments and how they contribute to the foundational knowledge of telomerase and telomere biology. View Full-Text
Keywords: telomerase; telomere; H/ACA ribonucleoprotein; small nucleolar RNA; small Cajal body RNA; spliceosome; exosome telomerase; telomere; H/ACA ribonucleoprotein; small nucleolar RNA; small Cajal body RNA; spliceosome; exosome
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MacNeil, D.E.; Bensoussan, H.J.; Autexier, C. Telomerase Regulation from Beginning to the End. Genes 2016, 7, 64.

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