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Genes 2016, 7(9), 61; doi:10.3390/genes7090061

Telomerase Activation in Hematological Malignancies

1
Cutaneous Lymphoma Oncogenesis Team INSERM U1053 Bordeaux Research in Translational Oncology, Bordeaux University, Bordeaux 33076, France
2
Institute of Biomedical Sciences of Abel Salazar, University of Porto, Porto 4050-313, Portugal
3
Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto 4200-135, Portugal
4
Institute of Molecular Pathology and Immunology of the University of Porto (Ipatimup)—Cancer Biology, Rua Dr. Roberto Frias, s/n, Porto 4200-465, Portugal
5
Tumor Bank and Tumor Biology Laboratory, University Hospital Center Bordeaux, Pessac 33604, France
6
Department of Pathology and Oncology, Medical Faculty of Porto University, Porto 4200-319, Portugal
*
Author to whom correspondence should be addressed.
Academic Editor: Gabriele Saretzki
Received: 1 June 2016 / Revised: 15 July 2016 / Accepted: 29 July 2016 / Published: 7 September 2016
(This article belongs to the Special Issue Telomerase Activity in Human Cells)
View Full-Text   |   Download PDF [237 KB, uploaded 7 September 2016]

Abstract

Telomerase expression and telomere maintenance are critical for cell proliferation and survival, and they play important roles in development and cancer, including hematological malignancies. Transcriptional regulation of the rate-limiting subunit of human telomerase reverse transcriptase gen (hTERT) is a complex process, and unveiling the mechanisms behind its reactivation is an important step for the development of diagnostic and therapeutic applications. Here, we review the main mechanisms of telomerase activation and the associated hematologic malignancies. View Full-Text
Keywords: telomerase activity; hematological malignancy; amplification; epigenetic; polymorphism; mutation; virus telomerase activity; hematological malignancy; amplification; epigenetic; polymorphism; mutation; virus
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Ropio, J.; Merlio, J.-P.; Soares, P.; Chevret, E. Telomerase Activation in Hematological Malignancies. Genes 2016, 7, 61.

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