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Genes 2016, 7(11), 93; doi:10.3390/genes7110093

Lack of TERT Promoter Mutations in Human B-Cell Non-Hodgkin Lymphoma

1
Department of Biology, Johns Hopkins University, Baltimore, MD 21210, USA
2
Department of Pathology, Johns Hopkins Medical Institutes, Baltimore, MD 212105, USA
3
Department of Pathology, University of California Los Angeles, Los Angeles, CA 90095, USA
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Gabriele Saretzki
Received: 12 August 2016 / Revised: 21 September 2016 / Accepted: 13 October 2016 / Published: 25 October 2016
(This article belongs to the Special Issue Telomerase Activity in Human Cells)
View Full-Text   |   Download PDF [382 KB, uploaded 25 October 2016]   |  

Abstract

Non-Hodgkin lymphomas (NHL) are a heterogeneous group of immune cell neoplasms that comprise molecularly distinct lymphoma subtypes. Recent work has identified high frequency promoter point mutations in the telomerase reverse transcriptase (TERT) gene of different cancer types, including melanoma, glioma, liver and bladder cancer. TERT promoter mutations appear to correlate with increased TERT expression and telomerase activity in these cancers. In contrast, breast, pancreatic, and prostate cancer rarely demonstrate mutations in this region of the gene. TERT promoter mutation prevalence in NHL has not been thoroughly tested thus far. We screened 105 B-cell lymphoid malignancies encompassing nine NHL subtypes and acute lymphoblastic leukemia, for TERT promoter mutations. Our results suggest that TERT promoter mutations are rare or absent in most NHL. Thus, the classical TERT promoter mutations may not play a major oncogenic role in TERT expression and telomerase activation in NHL. View Full-Text
Keywords: Telomerase; non-Hodgkin lymphoma; TERT promoter Telomerase; non-Hodgkin lymphoma; TERT promoter
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MDPI and ACS Style

Lam, G.; Xian, R.R.; Li, Y.; Burns, K.H.; Beemon, K.L. Lack of TERT Promoter Mutations in Human B-Cell Non-Hodgkin Lymphoma. Genes 2016, 7, 93.

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