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Genes 2016, 7(8), 54; doi:10.3390/genes7080054

Genetic Variants of Retinoic Acid Receptor-Related Orphan Receptor Alpha Determine Susceptibility to Type 2 Diabetes Mellitus in Han Chinese

1,†
,
2,†
,
2,†
,
2
and
2,*
1
Division of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu 610041, China
2
Molecular Medicine Research Center, West China Hospital, and State Key Laboratory of Biotherapy, Sichuan University, Chengdu 610041, China
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Josyf C. Mychaleckyj
Received: 2 June 2016 / Revised: 31 July 2016 / Accepted: 11 August 2016 / Published: 20 August 2016
(This article belongs to the Section Human Genomics and Genetic Diseases)
View Full-Text   |   Download PDF [519 KB, uploaded 23 August 2016]   |  

Abstract

Retinoic acid receptor-related orphan receptor alpha (RORA) plays a key role in the regulation of lipid and glucose metabolism and insulin expression that are implicated in the development of type 2 diabetes mellitus (T2DM). However, the effects of genetic variants in the RORA gene on the susceptibility to T2DM remain unknown. Nine tagging single-nucleotide polymorphisms (SNPs) were screened by using the SNaPshot method in 427 patients with T2DM and 408 normal controls. Association between genotypes and haplotypes derived from these SNPs with T2DM was analyzed using different genetic models. Allele and genotype frequencies at rs10851685 were significantly different between T2DM patients and control subjects (allele: p = 0.009, Odds ratios (OR) = 1.36 [95% Confidence intervals (CI) = 1.08–1.72]; genotype: p = 0.029). The minor allele T, at rs10851685, was potentially associated with an increased risk of T2DM in the dominant model, displaying OR of 1.38 (95% CI: 1.04–1.82, p = 0.025) in subjects with genotypes TA+TT vs. AA. In haplotype analysis, we observed that haplotypes GGTGTAACT, GGTGTAACC, and GATATAACT were significantly associated with increased risk of T2DM, while haplotypes GATGAAGTT, AGTGAAGTT, and AATGAAATT were protective against T2DM. These data suggest that the genetic variation in RORA might determine a Chinese Han individual’s susceptibility to T2DM. View Full-Text
Keywords: RORA; type 2 diabetes; gene variation; association; haplotype RORA; type 2 diabetes; gene variation; association; haplotype
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    Description: Nine SNPs in the RORA gene in the study

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MDPI and ACS Style

Zhang, Y.; Liu, Y.; Liu, Y.; Zhang, Y.; Su, Z. Genetic Variants of Retinoic Acid Receptor-Related Orphan Receptor Alpha Determine Susceptibility to Type 2 Diabetes Mellitus in Han Chinese. Genes 2016, 7, 54.

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