Replication-Associated Recombinational Repair: Lessons from Budding Yeast
AbstractRecombinational repair processes multiple types of DNA lesions. Though best understood in the repair of DNA breaks, recombinational repair is intimately linked to other situations encountered during replication. As DNA strands are decorated with many types of blocks that impede the replication machinery, a great number of genomic regions cannot be duplicated without the help of recombinational repair. This replication-associated recombinational repair employs both the core recombination proteins used for DNA break repair and the specialized factors that couple replication with repair. Studies from multiple organisms have provided insights into the roles of these specialized factors, with the findings in budding yeast being advanced through use of powerful genetics and methods for detecting DNA replication and repair intermediates. In this review, we summarize recent progress made in this organism, ranging from our understanding of the classical template switch mechanisms to gap filling and replication fork regression pathways. As many of the protein factors and biological principles uncovered in budding yeast are conserved in higher eukaryotes, these findings are crucial for stimulating studies in more complex organisms. View Full-Text
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Bonner, J.N.; Zhao, X. Replication-Associated Recombinational Repair: Lessons from Budding Yeast. Genes 2016, 7, 48.
Bonner JN, Zhao X. Replication-Associated Recombinational Repair: Lessons from Budding Yeast. Genes. 2016; 7(8):48.Chicago/Turabian Style
Bonner, Jaclyn N.; Zhao, Xiaolan. 2016. "Replication-Associated Recombinational Repair: Lessons from Budding Yeast." Genes 7, no. 8: 48.
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