Next Article in Journal / Special Issue
Human Specific Regulation of the Telomerase Reverse Transcriptase Gene
Previous Article in Journal
The MST/Hippo Pathway and Cell Death: A Non-Canonical Affair
Previous Article in Special Issue
Telomerase Activity is Downregulated Early During Human Brain Development
Article Menu

Export Article

Open AccessReview
Genes 2016, 7(6), 29; doi:10.3390/genes7060029

Role of Telomerase in the Cardiovascular System

1
IUF-Leibniz Research Institute for Environmental Medicine, 40225 Duesseldorf, Germany
2
Central Institute of Clinical Chemistry and Laboratory Medicine, Medical Faculty, University of Duesseldorf, 40225 Duesseldorf, Germany
These authors contribute equally
*
Author to whom correspondence should be addressed.
Academic Editor: Gabriele Saretzki
Received: 3 May 2016 / Revised: 6 June 2016 / Accepted: 14 June 2016 / Published: 17 June 2016
(This article belongs to the Special Issue Telomerase Activity in Human Cells)
View Full-Text   |   Download PDF [544 KB, uploaded 20 June 2016]   |  

Abstract

Aging is one major risk factor for the incidence of cardiovascular diseases and the development of atherosclerosis. One important enzyme known to be involved in aging processes is Telomerase Reverse Transcriptase (TERT). After the discovery of the enzyme in humans, TERT had initially only been attributed to germ line cells, stem cells and cancer cells. However, over the last few years it has become clear that TERT is also active in cells of the cardiovascular system including cardiac myocytes, endothelial cells, smooth muscle cells and fibroblasts. Interference with the activity of this enzyme greatly contributes to cardiovascular diseases. This review will summarize the findings on the role of TERT in cardiovascular cells. Moreover, recent findings concerning TERT in different mouse models with respect to cardiovascular diseases will be described. Finally, the extranuclear functions of TERT will be covered within this review. View Full-Text
Keywords: Telomerase Reverse Transcriptase; cardiovascular cells; aging Telomerase Reverse Transcriptase; cardiovascular cells; aging
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Zurek, M.; Altschmied, J.; Kohlgrüber, S.; Ale-Agha, N.; Haendeler, J. Role of Telomerase in the Cardiovascular System. Genes 2016, 7, 29.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Genes EISSN 2073-4425 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top