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Genes 2016, 7(6), 28; doi:10.3390/genes7060028

The MST/Hippo Pathway and Cell Death: A Non-Canonical Affair

1
Systems Biology Ireland, University College Dublin, Belfield, Dublin 4, Ireland
2
School of Medicine and Medical Science, University College Dublin, Belfield, Dublin 4, Ireland
Equal contribution.
*
Author to whom correspondence should be addressed.
Academic Editor: Paul Reynolds
Received: 10 May 2016 / Revised: 7 June 2016 / Accepted: 9 June 2016 / Published: 17 June 2016
(This article belongs to the Special Issue Hippo Signaling Pathway)
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Abstract

The MST/Hippo signalling pathway was first described over a decade ago in Drosophila melanogaster and the core of the pathway is evolutionary conserved in mammals. The mammalian MST/Hippo pathway regulates organ size, cell proliferation and cell death. In addition, it has been shown to play a central role in the regulation of cellular homeostasis and it is commonly deregulated in human tumours. The delineation of the canonical pathway resembles the behaviour of the Hippo pathway in the fly where the activation of the core kinases of the pathway prevents the proliferative signal mediated by the key effector of the pathway YAP. Nevertheless, several lines of evidence support the idea that the mammalian MST/Hippo pathway has acquired new features during evolution, including different regulators and effectors, crosstalk with other essential signalling pathways involved in cellular homeostasis and the ability to actively trigger cell death. Here we describe the current knowledge of the mechanisms that mediate MST/Hippo dependent cell death, especially apoptosis. We include evidence for the existence of complex signalling networks where the core proteins of the pathway play a central role in controlling the balance between survival and cell death. Finally, we discuss the possible involvement of these signalling networks in several human diseases such as cancer, diabetes and neurodegenerative disorders. View Full-Text
Keywords: Hippo pathway; signalling network; apoptosis; cancer; diabetes; neurodegenerative disease; YAP; MST1/2; LAST1/2; RASSF1A Hippo pathway; signalling network; apoptosis; cancer; diabetes; neurodegenerative disease; YAP; MST1/2; LAST1/2; RASSF1A
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Fallahi, E.; O’Driscoll, N.A.; Matallanas, D. The MST/Hippo Pathway and Cell Death: A Non-Canonical Affair. Genes 2016, 7, 28.

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