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Genes 2016, 7(6), 23; doi:10.3390/genes7060023

The Regulatory Role of KIBRA and PTPN14 in Hippo Signaling and Beyond

Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
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Author to whom correspondence should be addressed.
Academic Editor: Paul Reynolds
Received: 8 April 2016 / Revised: 17 May 2016 / Accepted: 19 May 2016 / Published: 27 May 2016
(This article belongs to the Special Issue Hippo Signaling Pathway)
View Full-Text   |   Download PDF [199 KB, uploaded 27 May 2016]

Abstract

The Hippo signaling pathway regulates cellular proliferation and survival, thus exerting profound effects on normal cell fate and tumorigenesis. Pivotal effectors of this pathway are YAP/TAZ, transcriptional co-activators whose dysfunction contributes to the development of cancer. Complex networks of intracellular and extracellular signaling pathways that modulate YAP and TAZ activities have recently been identified. Among them, KIBRA and PTPN14 are two evolutionarily-conserved and important YAP/TAZ upstream regulators. They can negatively regulate YAP/TAZ functions separately or in concert. In this review, we summarize the current and emerging regulatory roles of KIBRA and PTPN14 in the Hippo pathway and their functions in cancer. View Full-Text
Keywords: KIBRA; PTPN14; Hippo signaling pathway KIBRA; PTPN14; Hippo signaling pathway
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Wilson, K.E.; Yang, N.; Mussell, A.L.; Zhang, J. The Regulatory Role of KIBRA and PTPN14 in Hippo Signaling and Beyond. Genes 2016, 7, 23.

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