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Genes 2016, 7(4), 16; doi:10.3390/genes7040016

The R-Operon: A Model of Repetitive DNA-Organized Transcriptional Compartmentation of Eukaryotic Chromosomes for Coordinated Gene Expression

Department of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, TX 77555, USA
Academic Editor: J. Peter W. Young
Received: 8 February 2016 / Revised: 20 March 2016 / Accepted: 5 April 2016 / Published: 22 April 2016
(This article belongs to the Section Molecular Genetics)
View Full-Text   |   Download PDF [401 KB, uploaded 22 April 2016]   |  

Abstract

In eukaryotic genomes, it is essential to coordinate the activity of genes that function together to fulfill the same biological processes. Genomic organization likely plays a key role in coordinating transcription of different genes. However, little is known about how co-regulated genes are organized in the cell nucleus and how the chromosomal organization facilitates the co-regulation of different genes. I propose that eukaryotic genomes are organized into repeat assembly (RA)-based structural domains (“R-operons”) in the nuclear space. R-operons result from the interaction of homologous DNA repeats. In an R-operon, genes in different loci of the linear genome are brought into spatial vicinity and co-regulated by the same pool of transcription factors. This type of large-scale chromosomal organization may provide a mechanism for functional compartmentation of chromosomes to facilitate the transcriptional coordination of gene expression. View Full-Text
Keywords: chromosome; chromatin; transposon; repetitive DNA; DNA repeat; operon; transcription; gene expression; transcription factory chromosome; chromatin; transposon; repetitive DNA; DNA repeat; operon; transcription; gene expression; transcription factory
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Tang, S.-J. The R-Operon: A Model of Repetitive DNA-Organized Transcriptional Compartmentation of Eukaryotic Chromosomes for Coordinated Gene Expression. Genes 2016, 7, 16.

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