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Genes 2016, 7(10), 88; doi:10.3390/genes7100088

RNA Interference in Moths: Mechanisms, Applications, and Progress

1
State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan University, Kunming 650091, China
2
Institute of Plant Protection, Yunnan Academy of Forestry, Kunming 650201, China
3
School of Physical Education, Wenshan Institute, Wenshan 663000, China
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Academic Editor: Wenyi Gu
Received: 20 September 2016 / Revised: 13 October 2016 / Accepted: 14 October 2016 / Published: 19 October 2016
(This article belongs to the Special Issue RNA Interference 2016)
View Full-Text   |   Download PDF [275 KB, uploaded 19 October 2016]

Abstract

The vast majority of lepidopterans, about 90%, are moths. Some moths, particularly their caterpillars, are major agricultural and forestry pests in many parts of the world. However, some other members of moths, such as the silkworm Bombyx mori, are famous for their economic value. Fire et al. in 1998 initially found that exogenous double-stranded RNA (dsRNA) can silence the homolog endogenous mRNA in organisms, which is called RNA interference (RNAi). Soon after, the RNAi technique proved to be very promising not only in gene function determination but also in pest control. However, later studies demonstrate that performing RNAi in moths is not as straightforward as shown in other insect taxa. Nevertheless, since 2007, especially after 2010, an increasing number of reports have been published that describe successful RNAi experiments in different moth species either on gene function analysis or on pest management exploration. So far, more than 100 peer-reviewed papers have reported successful RNAi experiments in moths, covering 10 families and 25 species. By using classic and novel dsRNA delivery methods, these studies effectively silence the expression of various target genes and determine their function in larval development, reproduction, immunology, resistance against chemicals, and other biological processes. In addition, a number of laboratory and field trials have demonstrated that RNAi is also a potential strategy for moth pest management. In this review, therefore, we summarize and discuss the mechanisms and applications of the RNAi technique in moths by focusing on recent progresses. View Full-Text
Keywords: moths; RNAi; pest control; gene function; dsRNA moths; RNAi; pest control; gene function; dsRNA
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Xu, J.; Wang, X.-F.; Chen, P.; Liu, F.-T.; Zheng, S.-C.; Ye, H.; Mo, M.-H. RNA Interference in Moths: Mechanisms, Applications, and Progress. Genes 2016, 7, 88.

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