Achieving HIV-1 Control through RNA-Directed Gene Regulation
AbstractHIV-1 infection has been transformed by combined anti-retroviral therapy (ART), changing a universally fatal infection into a controllable infection. However, major obstacles for an HIV-1 cure exist. The HIV latent reservoir, which exists in resting CD4+ T cells, is not impacted by ART, and can reactivate when ART is interrupted or ceased. Additionally, multi-drug resistance can arise. One alternate approach to conventional HIV-1 drug treatment that is being explored involves gene therapies utilizing RNA-directed gene regulation. Commonly known as RNA interference (RNAi), short interfering RNA (siRNA) induce gene silencing in conserved biological pathways, which require a high degree of sequence specificity. This review will provide an overview of the silencing pathways, the current RNAi technologies being developed for HIV-1 gene therapy, current clinical trials, and the challenges faced in progressing these treatments into clinical trials. View Full-Text
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Klemm, V.; Mitchell, J.; Cortez-Jugo, C.; Cavalieri, F.; Symonds, G.; Caruso, F.; Kelleher, A.D.; Ahlenstiel, C. Achieving HIV-1 Control through RNA-Directed Gene Regulation. Genes 2016, 7, 119.
Klemm V, Mitchell J, Cortez-Jugo C, Cavalieri F, Symonds G, Caruso F, Kelleher AD, Ahlenstiel C. Achieving HIV-1 Control through RNA-Directed Gene Regulation. Genes. 2016; 7(12):119.Chicago/Turabian Style
Klemm, Vera; Mitchell, Jye; Cortez-Jugo, Christina; Cavalieri, Francesca; Symonds, Geoff; Caruso, Frank; Kelleher, Anthony D.; Ahlenstiel, Chantelle. 2016. "Achieving HIV-1 Control through RNA-Directed Gene Regulation." Genes 7, no. 12: 119.
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