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Genes 2015, 6(3), 512-519; doi:10.3390/genes6030512

Relation between ADIPOQ Gene Polymorphisms and Type 2 Diabetes

1
Golden Card Hospital, West China Hospital, Sichuan University, Chengdu 610041, China
2
Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu 610041, China
3
Department of Endocrinology, West China Hospital, Sichuan University, Chengdu 610041, China
*
Author to whom correspondence should be addressed.
Academic Editor: J. Peter W. Young
Received: 3 March 2015 / Revised: 30 June 2015 / Accepted: 1 July 2015 / Published: 8 July 2015
View Full-Text   |   Download PDF [101 KB, uploaded 8 July 2015]

Abstract

Objective: The manuscript investigates the relation between adiponectin gene (ADIPOQ) polymorphisms and type 2 diabetes mellitus (T2DM) in a Chinese population. Methods: We designed a case-control study involving 340 normal glucose tolerant (NGT) subjects and 340 type 2 diabetes patients. Three SNPs (rs182052, rs1501299, and rs7627128) were genotyped by TaqMan methods. Results: We found that rs7627128, rs1501299 and rs182052 were significantly associated with T2DM. Haplotypes analysis indicated that the frequency of the haplotypes A-A-T was frequent in T2DM patients (OR = 2.10; 95%CI: 1.44–2.90; p < 0.001), but G-A-T was more frequent in the control group than in the T2DM group (OR = 0.66; 95%CI: 0.54–0.81; p < 0.001). Conclusion: The ADIPOQ genetic polymorphisms were associated with type 2 diabetes in a Chinese population. View Full-Text
Keywords: ADIPOQ; type 2 diabetes; genetic polymorphism; case-control study ADIPOQ; type 2 diabetes; genetic polymorphism; case-control study
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Li, Z.-P.; Zhang, M.; Gao, J.; Zhou, G.-Y.; Li, S.-Q.; An, Z.-M. Relation between ADIPOQ Gene Polymorphisms and Type 2 Diabetes. Genes 2015, 6, 512-519.

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