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Association Claims in the Sequencing Era
AbstractSince the completion of the Human Genome Project, the field of human genetics has been in great flux, largely due to technological advances in studying DNA sequence variation. Although community-wide adoption of statistical standards was key to the success of genome-wide association studies, similar standards have not yet been globally applied to the processing and interpretation of sequencing data. It has proven particularly challenging to pinpoint unequivocally disease variants in sequencing studies of polygenic traits. Here, we comment on a number of factors that may contribute to irreproducible claims of association in scientific literature and discuss possible steps that we can take towards cultural change.
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Pulit, S.L.; Leusink, M.; Menelaou, A.; de Bakker, P.I.W. Association Claims in the Sequencing Era. Genes 2014, 5, 196-213.View more citation formats
Pulit SL, Leusink M, Menelaou A, de Bakker PIW. Association Claims in the Sequencing Era. Genes. 2014; 5(1):196-213.Chicago/Turabian Style
Pulit, Sara L.; Leusink, Maarten; Menelaou, Androniki; de Bakker, Paul I.W. 2014. "Association Claims in the Sequencing Era." Genes 5, no. 1: 196-213.