Next Article in Journal
Matricellular Signal Transduction Involving Calmodulin in the Social Amoebozoan Dictyostelium
Next Article in Special Issue
A Novel Function for the Conserved Glutamate Residue in the Walker B Motif of Replication Factor C
Previous Article in Journal
The Sound of Silence: RNAi in Poly (ADP-Ribose) Research
Previous Article in Special Issue
Modeling of the SV40 DNA Replication Machine
Genes 2013, 4(1), 1-32; doi:10.3390/genes4010001
Review

The Replication Fork: Understanding the Eukaryotic Replication Machinery and the Challenges to Genome Duplication

†,*  and *
Received: 3 December 2012; in revised form: 21 January 2013 / Accepted: 22 January 2013 / Published: 29 January 2013
(This article belongs to the Special Issue DNA Replication)
View Full-Text   |   Download PDF [681 KB, uploaded 29 January 2013]   |   Browse Figures
Abstract: Eukaryotic cells must accurately and efficiently duplicate their genomes during each round of the cell cycle. Multiple linear chromosomes, an abundance of regulatory elements, and chromosome packaging are all challenges that the eukaryotic DNA replication machinery must successfully overcome. The replication machinery, the “replisome” complex, is composed of many specialized proteins with functions in supporting replication by DNA polymerases. Efficient replisome progression relies on tight coordination between the various factors of the replisome. Further, replisome progression must occur on less than ideal templates at various genomic loci. Here, we describe the functions of the major replisome components, as well as some of the obstacles to efficient DNA replication that the replisome confronts. Together, this review summarizes current understanding of the vastly complicated task of replicating eukaryotic DNA.
Keywords: DNA replication; replisome; replication fork; genome stability; checkpoint; fork barriers; difficult-to-replicate sites DNA replication; replisome; replication fork; genome stability; checkpoint; fork barriers; difficult-to-replicate sites
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

Leman, A.R.; Noguchi, E. The Replication Fork: Understanding the Eukaryotic Replication Machinery and the Challenges to Genome Duplication. Genes 2013, 4, 1-32.

AMA Style

Leman AR, Noguchi E. The Replication Fork: Understanding the Eukaryotic Replication Machinery and the Challenges to Genome Duplication. Genes. 2013; 4(1):1-32.

Chicago/Turabian Style

Leman, Adam R.; Noguchi, Eishi. 2013. "The Replication Fork: Understanding the Eukaryotic Replication Machinery and the Challenges to Genome Duplication." Genes 4, no. 1: 1-32.


Genes EISSN 2073-4425 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert