Next Article in Journal
Comparative Genomics of Aeschynomene Symbionts: Insights into the Ecological Lifestyle of Nod-Independent Photosynthetic Bradyrhizobia
Next Article in Special Issue
Biological Complexities in Radiation Carcinogenesis and Cancer Radiotherapy: Impact of New Biological Paradigms
Previous Article in Journal
Comparison of the Fecal Microbiota in Feral and Domestic Goats
Previous Article in Special Issue
Modeling the Risk of Secondary Malignancies after Radiotherapy
Genes 2012, 3(1), 19-34; doi:10.3390/genes3010019

Discriminating Gene Expression Signature of Radiation-Induced Thyroid Tumors after Either External Exposure or Internal Contamination

1,* , 1
1 CEA, DSV, IRCM, SREIT, Laboratoire de Cancérologie Expérimentale, BP6, Fontenay-aux-Roses, F-92265, France 2 Institut Gustave Roussy, Department on Nuclear Medicine and Endocrine Oncology, Villejuif, and University Paris-Sud, F-94800, France 3 INSERM ERI-21, Nice, F-06002, France 4 University of Nice-Sophia Antipolis, IFR 50, Nice, F-06002, France 5 Laboratory of Clinical and Experimental Pathology and CHU-CRLCC-UNSA tumour tissue bank of Nice area, Louis Pasteur Hospital, Nice, F-06002, France
* Author to whom correspondence should be addressed.
Received: 3 November 2011 / Revised: 6 December 2011 / Accepted: 9 December 2011 / Published: 21 December 2011
(This article belongs to the Special Issue Radiation-Related Cancer 25 Years After Chernobyl)
View Full-Text   |   Download PDF [889 KB, uploaded 21 December 2011]   |   Browse Figure


Both external radiation exposure and internal radionuclide contamination are well known risk factors in the development of thyroid epithelial tumors. The identification of specific molecular markers deregulated in radiation-induced thyroid tumors is important for the etiological diagnosis since neither histological features nor genetic alterations can discriminate between sporadic and radiation-induced tumors. Identification of highly discriminating markers in radiation-induced tumors is challenging as it relies on the ability to identify marker deregulation which is associated with a cellular stress that occurred many years before in the thyroid cells. The existence of such a signature is still controversial, as it was not found in several studies while a highly discriminating signature was found in both post-radiotherapy and post-Chernobyl series in other studies. Overall, published studies searching for radiation-induced thyroid tumor specificities, using transcriptomic, proteomic and comparative genomic hybridization approaches, and bearing in mind the analytical constraints required to analyze such small series of tumors, suggest that such a molecular signature could be found. In comparison with sporadic tumors, we highlight molecular similarities and specificities in tumors occurring after high-dose external radiation exposure, such as radiotherapy, and in post-Chernobyl tumors that occurred after internal 131I contamination. We discuss the relevance of signature extrapolation from series of tumors developing after high and low doses in the identification of tumors induced at very low doses of radiation.
Keywords: thyroid; radiation-induced tumors; transcriptomic signature; molecular epidemiology thyroid; radiation-induced tumors; transcriptomic signature; molecular epidemiology
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Supplementary materials


Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote |
MDPI and ACS Style

Ory, C.; Ugolin, N.; Schlumberger, M.; Hofman, P.; Chevillard, S. Discriminating Gene Expression Signature of Radiation-Induced Thyroid Tumors after Either External Exposure or Internal Contamination. Genes 2012, 3, 19-34.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here


[Return to top]
Genes EISSN 2073-4425 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert