Next Article in Journal / Special Issue
Gene Conversion in Angiosperm Genomes with an Emphasis on Genes Duplicated by Polyploidization
Previous Article in Journal
Initiation of Meiotic Recombination in Mammals
Previous Article in Special Issue
Genomic and Population-Level Effects of Gene Conversion in Caenorhabditis Paralogs
Genes 2010, 1(3), 550-563; doi:10.3390/genes1030550
Review

Gene Conversion in Human Genetic Disease

1,2,3,* , 1,2,3,4
 and 5
1 Institut National de la Santé et de la Recherche Médicale (INSERM), U613, Brest, France 2 Etablissement Français du Sang (EFS)-Bretagne, Brest, France 3 Faculté de Médecine et des Sciences de la Santé, Université de Bretagne Occidentale (UBO), Brest, France 4 Laboratoire de Génétique Moléculaire et d’Histocompatibilité, Centre Hospitalier Universitaire (CHU) de Brest, Hôpital Morvan, Brest, France 5 Institute of Medical Genetics, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
* Author to whom correspondence should be addressed.
Received: 15 October 2010 / Revised: 12 November 2010 / Accepted: 17 November 2010 / Published: 22 December 2010
(This article belongs to the Special Issue Gene Conversion in Duplicated Genes)
View Full-Text   |   Download PDF [320 KB, uploaded 22 December 2010]   |   Browse Figures

Abstract

Gene conversion is a specific type of homologous recombination that involves the unidirectional transfer of genetic material from a ‘donor’ sequence to a highly homologous ‘acceptor’. We have recently reviewed the molecular mechanisms underlying gene conversion, explored the key part that this process has played in fashioning extant human genes, and performed a meta-analysis of gene-conversion events known to have caused human genetic disease. Here we shall briefly summarize some of the latest developments in the study of pathogenic gene conversion events, including (i) the emerging idea of minimal efficient sequence homology (MESH) for homologous recombination, (ii) the local DNA sequence features that appear to predispose to gene conversion, (iii) a mechanistic comparison of gene conversion and transient hypermutability, and (iv) recently reported examples of pathogenic gene conversion events.
Keywords: gene conversion mutation; homologous recombination; human inherited disease gene conversion mutation; homologous recombination; human inherited disease
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Export to BibTeX |
EndNote


MDPI and ACS Style

Chen, J.-M.; Férec, C.; Cooper, D.N. Gene Conversion in Human Genetic Disease. Genes 2010, 1, 550-563.

View more citation formats

Related Articles

Article Metrics

Comments

Citing Articles

[Return to top]
Genes EISSN 2073-4425 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert