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Initiation of Meiotic Recombination in Mammals
Institute of Human Genetics, UPR1142, CNRS, 141 rue de la Cardonille, 34396 Montpellier cedex 5, France
* Author to whom correspondence should be addressed.
Received: 1 November 2010; in revised form: 22 November 2010 / Accepted: 3 December 2010 / Published: 22 December 2010
Abstract: Meiotic recombination is initiated by the induction of programmed DNA double strand breaks (DSBs). DSB repair promotes homologous interactions and pairing and leads to the formation of crossovers (COs), which are required for the proper reductional segregation at the first meiotic division. In mammals, several hundred DSBs are generated at the beginning of meiotic prophase by the catalytic activity of SPO11. Currently it is not well understood how the frequency and timing of DSB formation and their localization are regulated. Several approaches in humans and mice have provided an extensive description of the localization of initiation events based on CO mapping, leading to the identification and characterization of preferred sites (hotspots) of initiation. This review presents the current knowledge about the proteins known to be involved in this process, the sites where initiation takes place, and the factors that control hotspot localization.
Keywords: Meiosis; hotspot; DSB; crossover; recombination; Spo11; Mei1; Mei4; Prdm9
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Kumar, R.; De Massy, B. Initiation of Meiotic Recombination in Mammals. Genes 2010, 1, 521-549.
Kumar R, De Massy B. Initiation of Meiotic Recombination in Mammals. Genes. 2010; 1(3):521-549.
Kumar, Rajeev; De Massy, Bernard. 2010. "Initiation of Meiotic Recombination in Mammals." Genes 1, no. 3: 521-549.