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Cells 2017, 6(3), 22; doi:10.3390/cells6030022

Exploring Autophagy in Drosophila

1
Department of Anatomy, Cell and Developmental Biology, Eötvös Loránd University, H-1117 Budapest, Hungary
2
Catalan Institute of Oncology-IDIBELL, Laboratory of Cancer Metabolism (LMC), Hospital Duran i Reynals, 08908 Barcelona, Spain
3
Institute of Genetics, Biological Research Centre, Hungarian Academy of Sciences, H-6726 Szeged, Hungary
*
Author to whom correspondence should be addressed.
Received: 17 June 2017 / Revised: 6 July 2017 / Accepted: 8 July 2017 / Published: 12 July 2017
(This article belongs to the Special Issue Assays to Monitor Autophagy in Model Systems)
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Abstract

Autophagy is a catabolic process in eukaryotic cells promoting bulk or selective degradation of cellular components within lysosomes. In recent decades, several model systems were utilized to dissect the molecular machinery of autophagy and to identify the impact of this cellular “self-eating” process on various physiological and pathological processes. Here we briefly discuss the advantages and limitations of using the fruit fly Drosophila melanogaster, a popular model in cell and developmental biology, to apprehend the main pathway of autophagy in a complete animal. View Full-Text
Keywords: Atg8a; autophagy; Drosophila; Ref(2)P/p62 Atg8a; autophagy; Drosophila; Ref(2)P/p62
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Lőrincz, P.; Mauvezin, C.; Juhász, G. Exploring Autophagy in Drosophila. Cells 2017, 6, 22.

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