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Cells 2017, 6(3), 21; doi:10.3390/cells6030021

Studying Autophagy in Zebrafish

1
Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo, Sognsvannsveien 9, 0317 Oslo, Norway
2
Institute of Biology Leiden, Leiden University, Einsteinweg 55, 2333 CC Leiden, The Netherlands
*
Author to whom correspondence should be addressed.
Received: 7 June 2017 / Revised: 1 July 2017 / Accepted: 3 July 2017 / Published: 9 July 2017
(This article belongs to the Special Issue Assays to Monitor Autophagy in Model Systems)
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Abstract

Autophagy is an evolutionarily conserved catabolic process which allows lysosomal degradation of complex cytoplasmic components into basic biomolecules that are recycled for further cellular use. Autophagy is critical for cellular homeostasis and for degradation of misfolded proteins and damaged organelles as well as intracellular pathogens. The role of autophagy in protection against age-related diseases and a plethora of other diseases is now coming to light; assisted by several divergent eukaryotic model systems ranging from yeast to mice. We here give an overview of different methods used to analyse autophagy in zebrafish—a relatively new model for studying autophagy—and briefly discuss what has been done so far and possible future directions. View Full-Text
Keywords: autophagy; zebrafish; GFP-Lc3; confocal microscopy; mitophagy; aggrephagy; xenophagy autophagy; zebrafish; GFP-Lc3; confocal microscopy; mitophagy; aggrephagy; xenophagy
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Mathai, B.J.; Meijer, A.H.; Simonsen, A. Studying Autophagy in Zebrafish. Cells 2017, 6, 21.

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