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Cells 2016, 5(2), 18; doi:10.3390/cells5020018

Vimentin in Bacterial Infections

Department of Biomedicine, Aarhus University, 8000 Aarhus C, Denmark
Present address: Janssen Prevention Center, Archimedesweg 6, 2333CN Leiden, The Netherlands
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Author to whom correspondence should be addressed.
Academic Editor: Rudolf Leube
Received: 1 March 2016 / Revised: 31 March 2016 / Accepted: 12 April 2016 / Published: 18 April 2016
(This article belongs to the Special Issue Beyond Cell Mechanics: Novel Functions of Intermediate Filaments)
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Abstract

Despite well-studied bacterial strategies to target actin to subvert the host cell cytoskeleton, thus promoting bacterial survival, replication, and dissemination, relatively little is known about the bacterial interaction with other components of the host cell cytoskeleton, including intermediate filaments (IFs). IFs have not only roles in maintaining the structural integrity of the cell, but they are also involved in many cellular processes including cell adhesion, immune signaling, and autophagy, processes that are important in the context of bacterial infections. Here, we summarize the knowledge about the role of IFs in bacterial infections, focusing on the type III IF protein vimentin. Recent studies have revealed the involvement of vimentin in host cell defenses, acting as ligand for several pattern recognition receptors of the innate immune system. Two main aspects of bacteria-vimentin interactions are presented in this review: the role of vimentin in pathogen-binding on the cell surface and subsequent bacterial invasion and the interaction of cytosolic vimentin and intracellular pathogens with regards to innate immune signaling. Mechanistic insight is presented involving distinct bacterial virulence factors that target vimentin to subvert its function in order to change the host cell fate in the course of a bacterial infection. View Full-Text
Keywords: vimentin; intermediate filament; innate immune signaling; pattern recognition receptor; NOD2; NF-kB; reactive oxygen species; intracellular pathogen; bacterial infection vimentin; intermediate filament; innate immune signaling; pattern recognition receptor; NOD2; NF-kB; reactive oxygen species; intracellular pathogen; bacterial infection
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Mak, T.N.; Brüggemann, H. Vimentin in Bacterial Infections. Cells 2016, 5, 18.

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