Next Article in Journal
A Heterozygous ZMPSTE24 Mutation Associated with Severe Metabolic Syndrome, Ectopic Fat Accumulation, and Dilated Cardiomyopathy
Next Article in Special Issue
The Hagfish Gland Thread Cell: A Fiber-Producing Cell Involved in Predator Defense
Previous Article in Journal
Generation and Characterization of Vascular Smooth Muscle Cell Lines Derived from a Patient with a Bicuspid Aortic Valve
Previous Article in Special Issue
Vimentin in Bacterial Infections
Article Menu

Export Article

Open AccessReview
Cells 2016, 5(2), 20; doi:10.3390/cells5020020

Role of Intermediate Filaments in Vesicular Traffic

Department of Biological and Environmental Sciences and Technologies (DiSTeBA), University of Salento, Via Provinciale Lecce-Monteroni 165, 73100 Lecce, Italy
*
Author to whom correspondence should be addressed.
Academic Editor: Rudolf E. Leube
Received: 23 March 2016 / Revised: 13 April 2016 / Accepted: 20 April 2016 / Published: 25 April 2016
(This article belongs to the Special Issue Beyond Cell Mechanics: Novel Functions of Intermediate Filaments)
View Full-Text   |   Download PDF [1472 KB, uploaded 25 April 2016]   |  

Abstract

Intermediate filaments are an important component of the cellular cytoskeleton. The first established role attributed to intermediate filaments was the mechanical support to cells. However, it is now clear that intermediate filaments have many different roles affecting a variety of other biological functions, such as the organization of microtubules and microfilaments, the regulation of nuclear structure and activity, the control of cell cycle and the regulation of signal transduction pathways. Furthermore, a number of intermediate filament proteins have been involved in the acquisition of tumorigenic properties. Over the last years, a strong involvement of intermediate filament proteins in the regulation of several aspects of intracellular trafficking has strongly emerged. Here, we review the functions of intermediate filaments proteins focusing mainly on the recent knowledge gained from the discovery that intermediate filaments associate with key proteins of the vesicular membrane transport machinery. In particular, we analyze the current understanding of the contribution of intermediate filaments to the endocytic pathway. View Full-Text
Keywords: intermediate filaments; intracellular trafficking; endocytosis; exocytosis; vimentin; membrane traffic; mitosis intermediate filaments; intracellular trafficking; endocytosis; exocytosis; vimentin; membrane traffic; mitosis
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Margiotta, A.; Bucci, C. Role of Intermediate Filaments in Vesicular Traffic. Cells 2016, 5, 20.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Cells EISSN 2073-4409 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top