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Cells 2016, 5(2), 16; doi:10.3390/cells5020016

The NF-κB Pathway and Cancer Stem Cells

1
Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC 27599, USA
2
Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Ruaidhri Carmody
Received: 10 February 2016 / Revised: 30 March 2016 / Accepted: 31 March 2016 / Published: 6 April 2016
(This article belongs to the Special Issue Cellular and Molecular Biology of NF-κB)
View Full-Text   |   Download PDF [1086 KB, uploaded 6 April 2016]   |  

Abstract

The NF-κB transcription factor pathway is a crucial regulator of inflammation and immune responses. Additionally, aberrant NF-κB signaling has been identified in many types of cancer. Downstream of key oncogenic pathways, such as RAS, BCR-ABL, and Her2, NF-κB regulates transcription of target genes that promote cell survival and proliferation, inhibit apoptosis, and mediate invasion and metastasis. The cancer stem cell model posits that a subset of tumor cells (cancer stem cells) drive tumor initiation, exhibit resistance to treatment, and promote recurrence and metastasis. This review examines the evidence for a role for NF-κB signaling in cancer stem cell biology. View Full-Text
Keywords: NF-κB; cancer; cancer stem cells; tumor-initiating cells; self-renewal NF-κB; cancer; cancer stem cells; tumor-initiating cells; self-renewal
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Rinkenbaugh, A.L.; Baldwin, A.S. The NF-κB Pathway and Cancer Stem Cells. Cells 2016, 5, 16.

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