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Cells 2016, 5(2), 17; doi:10.3390/cells5020017

The Regulation of Cellular Responses to Mechanical Cues by Rho GTPases

1
School of Biological Sciences, Nanyang Technological University, Singapore 637551, Singapore
2
Mechanobiology Institute, Singapore 117411, Singapore
*
Author to whom correspondence should be addressed.
Academic Editor: Bor Luen Tang
Received: 16 December 2015 / Revised: 29 March 2016 / Accepted: 30 March 2016 / Published: 6 April 2016
(This article belongs to the Special Issue Regulation and Function of Small GTPases)
View Full-Text   |   Download PDF [511 KB, uploaded 6 April 2016]   |  

Abstract

The Rho GTPases regulate many cellular signaling cascades that modulate cell motility, migration, morphology and cell division. A large body of work has now delineated the biochemical cues and pathways, which stimulate the GTPases and their downstream effectors. However, cells also respond exquisitely to biophysical and mechanical cues such as stiffness and topography of the extracellular matrix that profoundly influence cell migration, proliferation and differentiation. As these cellular responses are mediated by the actin cytoskeleton, an involvement of Rho GTPases in the transduction of such cues is not unexpected. In this review, we discuss an emerging role of Rho GTPase proteins in the regulation of the responses elicited by biophysical and mechanical stimuli. View Full-Text
Keywords: Rho GTPases; matrix stiffness; topography; actin cytoskeleton; mechanical cues; biophysical cues; cell migration; proliferation and differentiation Rho GTPases; matrix stiffness; topography; actin cytoskeleton; mechanical cues; biophysical cues; cell migration; proliferation and differentiation
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Hoon, J.L.; Tan, M.H.; Koh, C.-G. The Regulation of Cellular Responses to Mechanical Cues by Rho GTPases. Cells 2016, 5, 17.

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