Next Article in Journal
The Regulation of Cellular Responses to Mechanical Cues by Rho GTPases
Next Article in Special Issue
The NF-κB Pathway and Cancer Stem Cells
Previous Article in Journal / Special Issue
Regulation of the Adaptive Immune Response by the IκB Family Protein Bcl-3
Article Menu

Export Article

Open AccessReview
Cells 2016, 5(2), 15; doi:10.3390/cells5020015

Roles of NF-κB in Cancer and Inflammatory Diseases and Their Therapeutic Approaches

College of Pharmacy and Medical Research Center, Chungbuk National University, 194-31, Osongsaengmyeong 1-ro, Osong-eup, Cheongwon-gun, Chungbuk 28160, Korea
*
Author to whom correspondence should be addressed.
Academic Editor: Ruaidhri Carmody
Received: 22 February 2016 / Revised: 22 March 2016 / Accepted: 24 March 2016 / Published: 29 March 2016
(This article belongs to the Special Issue Cellular and Molecular Biology of NF-κB)
View Full-Text   |   Download PDF [1171 KB, uploaded 29 March 2016]   |  

Abstract

Nuclear factor-κB (NF-κB) is a transcription factor that plays a crucial role in various biological processes, including immune response, inflammation, cell growth and survival, and development. NF-κB is critical for human health, and aberrant NF-κB activation contributes to development of various autoimmune, inflammatory and malignant disorders including rheumatoid arthritis, atherosclerosis, inflammatory bowel diseases, multiple sclerosis and malignant tumors. Thus, inhibiting NF-κB signaling has potential therapeutic applications in cancer and inflammatory diseases. View Full-Text
Keywords: NF-κB; canonical pathway; non-canonical pathway; cancer; inflammatory disease; therapeutic approaches NF-κB; canonical pathway; non-canonical pathway; cancer; inflammatory disease; therapeutic approaches
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Park, M.H.; Hong, J.T. Roles of NF-κB in Cancer and Inflammatory Diseases and Their Therapeutic Approaches. Cells 2016, 5, 15.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Cells EISSN 2073-4409 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top