Regulation of the Adaptive Immune Response by the IκB Family Protein Bcl-3
AbstractBcl-3 is a member of the IκB family of proteins and an important regulator of Nuclear Factor (NF)-κB activity. The ability of Bcl-3 to bind and regulate specific NF-κB dimers has been studied in great depth, but its physiological roles in vivo are still not fully understood. It is, however, becoming clear that Bcl-3 is essential for the proper development, survival and activity of adaptive immune cells. Bcl-3 dysregulation can be observed in a number of autoimmune pathologies, and Bcl3-deficient animals are more susceptible to bacterial and parasitic infection. This review will describe our current understanding of the roles played by Bcl-3 in the development and regulation of the adaptive immune response, including lymphoid organogenesis, immune tolerance, lymphocyte function and dendritic cell biology. View Full-Text
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Herrington, F.D.; Nibbs, R.J.B. Regulation of the Adaptive Immune Response by the IκB Family Protein Bcl-3. Cells 2016, 5, 14.
Herrington FD, Nibbs RJB. Regulation of the Adaptive Immune Response by the IκB Family Protein Bcl-3. Cells. 2016; 5(2):14.Chicago/Turabian Style
Herrington, Felicity D.; Nibbs, Robert J.B. 2016. "Regulation of the Adaptive Immune Response by the IκB Family Protein Bcl-3." Cells 5, no. 2: 14.
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