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Cells 2016, 5(2), 14; doi:10.3390/cells5020014

Regulation of the Adaptive Immune Response by the IκB Family Protein Bcl-3

Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow G12 8TA, Scotland, UK
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Academic Editor: Alexander E. Kalyuzhny
Received: 8 February 2016 / Revised: 17 March 2016 / Accepted: 17 March 2016 / Published: 24 March 2016
(This article belongs to the Special Issue Cellular and Molecular Biology of NF-κB)
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Abstract

Bcl-3 is a member of the IκB family of proteins and an important regulator of Nuclear Factor (NF)-κB activity. The ability of Bcl-3 to bind and regulate specific NF-κB dimers has been studied in great depth, but its physiological roles in vivo are still not fully understood. It is, however, becoming clear that Bcl-3 is essential for the proper development, survival and activity of adaptive immune cells. Bcl-3 dysregulation can be observed in a number of autoimmune pathologies, and Bcl3-deficient animals are more susceptible to bacterial and parasitic infection. This review will describe our current understanding of the roles played by Bcl-3 in the development and regulation of the adaptive immune response, including lymphoid organogenesis, immune tolerance, lymphocyte function and dendritic cell biology. View Full-Text
Keywords: NF-κB; Bcl-3; adaptive immunity; inflammation NF-κB; Bcl-3; adaptive immunity; inflammation
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Herrington, F.D.; Nibbs, R.J.B. Regulation of the Adaptive Immune Response by the IκB Family Protein Bcl-3. Cells 2016, 5, 14.

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